Flashcards in Carcinogenesis Deck (13):
A complete carcinogen is capable of both ____ and _____
Initiation and Promotion
Name five commonly discussed carcinogenic chemicals
1. Alkylating Agents
2. Polycyclic Aromatic Hydrocarbons (tobacco, broiled fats, smoked meat)
3. Aromatic Amines/Azo Dyes (NAP, Aniline dyes, rubber)
4. Nitosamines + Amides
5. Natural (Aflatoxin Ba -- Aspergillus flavus)
Five less common wild-card carcinogenic chemicals
2. Vinyl chloride
3. Chromium, Nickel
Important chemical promoters of cancer
Saccharin and Cyclamates
Dietary fat (colon)
X-ray/Gamma ray. Direct or Indirect action radiation injury?
Particulate radiation. Direct or Indirect action radiation injury?
Radiant energy. Direct or Indirect action radiation injury?
Exposure to UV light leads to....
Formation of pyridimine dimers in the DNA
Damage to ras and p53
Who gets ionizing radiation? What cancer do they get? (5)
1. Radioactive element miners (Lung)
2. Atomic Bomb Survivors (Leukemia)
3. Therapeutic Exposure (Thyroid)
4. Marshall Islands (Thyroid)
5. Radium Dial Painters (Mouth, Throat)
Whats the deal with xeroderma pigmentosum?
Inability to excise pyrimidine dimers formed on exposure to UV radiation.
How does HPV cause cancer?
Viral protein E7 binds to Rb gene
Viral protain E6 binds p53
EBV is associated with incidence of which cancers?
B-cell lymphoma (in immunosuppressed)