Carcinogenesis Flashcards Preview

Pathology -- Gen Path > Carcinogenesis > Flashcards

Flashcards in Carcinogenesis Deck (13):
1

A complete carcinogen is capable of both ____ and _____

Initiation and Promotion

2

Name five commonly discussed carcinogenic chemicals

1. Alkylating Agents
2. Polycyclic Aromatic Hydrocarbons (tobacco, broiled fats, smoked meat)
3. Aromatic Amines/Azo Dyes (NAP, Aniline dyes, rubber)
4. Nitosamines + Amides
5. Natural (Aflatoxin Ba -- Aspergillus flavus)

3

Five less common wild-card carcinogenic chemicals

1. Asbestos
2. Vinyl chloride
3. Chromium, Nickel
4. Arsenic
5. Insectisides

4

Important chemical promoters of cancer

Saccharin and Cyclamates
Estrogens
Diethylstilbestrol (endometrial)
Dietary fat (colon)

5

X-ray/Gamma ray. Direct or Indirect action radiation injury?

Indirect

6

Particulate radiation. Direct or Indirect action radiation injury?

Direct

7

Radiant energy. Direct or Indirect action radiation injury?

Both

8

Exposure to UV light leads to....

Formation of pyridimine dimers in the DNA
Damage to ras and p53

9

Who gets ionizing radiation? What cancer do they get? (5)

1. Radioactive element miners (Lung)
2. Atomic Bomb Survivors (Leukemia)
3. Therapeutic Exposure (Thyroid)
4. Marshall Islands (Thyroid)
5. Radium Dial Painters (Mouth, Throat)

10

Whats the deal with xeroderma pigmentosum?

Inability to excise pyrimidine dimers formed on exposure to UV radiation.

11

How does HPV cause cancer?

Viral protein E7 binds to Rb gene
Viral protain E6 binds p53

12

EBV is associated with incidence of which cancers?

Burkitt's lymphoma
B-cell lymphoma (in immunosuppressed)
Hodgin's Disease
Nasopharyngeal carcinoma

13

RNA virus associated with cancer?

Human T-cell leukemia virus 1
Adult T-cell leukemia/lymphoma

Also..Hep C