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Lab Medicine > Cardiac > Flashcards

Flashcards in Cardiac Deck (27):
1

Type 1 MI

Spontaneous MI related to intraluminal thrombus with ensuing myocyte necrosis

2

Type 2

MI 2ary to an ischemic imbalance between myocardial O2 supply &/or demand

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Type 3

MI resulting in death when biomarker values are unavailable

4

Type 4a

MI related to PCI

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Type 4b

MI related to stent thrombosis

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Type 5

MI related to CABG

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Cardiac troponin I (cTnI) reference range

<0.07 ng/mL

8

Cardiac troponin T (cTnT) reference range

<0.01 ng/mL

9

Creatine Kinase MB isoenzyme (CKMB) reference range

<10 ng/mL

10

Myoglobin reference range

<70 ng/mL
(>25% increase over 90 min suggests AMI)

11

CK elevations in serum after MI

1st elevation: 4-6 hrs
Peak elevation: 18-36 hrs
Duration of elevation: 3 days

12

Myoglobin elevations in serum after MI

1st elevation: 2-3 hrs
Peak elevation: 6-9 hrs
Duration of elevation: 1 day

13

Troponin I & T elevations in serum after MI

1st elevation: 4-6 hrs
Peak elevation: 24-36 hrs
Duration of elevation: depends on extent of damage

14

Creatine Kinase Relative Index CKRI

CK Index = (CKMB mass (ng/Ml) * 100 )/ (Total CK activity (U/L) )

15

Normal CKRI

CKMB < 10 ng/mL and an index < 2.5

16

Cardiac Damage CKRI

CKMB > 10 ng/mL and an index > 2.5

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Skeletal Muscle Damage CKRI

CKMB > 10 ng/mL and an index < 2.5

18

Specificity of Myoglobin as a biomarker

70%

19

Specificity of CKMB as a biomarker

95%

20

Specificity of Troponin as a biomarker

> 95%

21

Highest Sensitivity of Myoglobin as a biomark

2-8 hrs: 95%

22

Sensitivity of CKMB as a biomarker

24-72 hrs: 98%

23

Sensitivity of Troponin as a biomarker

24-72+ hrs: 98%

24

BNP (77-108) Reference Range

<100 pg/mL

25

NT-pro-BNP (1-76) if less than 50 years old

<450 pg/mL

26

NT-pro-BNP (1-76) if between 50 and 75 years old

<900 pg/mL

27

NT-pro-BNP (1-76) if greater than 75 years old

<1800 pg/mL