antiarrhythmic - QT prolongation
reduce his blood pressure and slow the damaging effects of diabetes on his renal and cardiovascular systems
ACE side effect
Hyperkalemia / myopathy - CYP3A4
diltiazem - EKG
Prolongation of the PR interval
used as first-line therapy to achieve diuresis in patients with pulmonary edema due to CHF exacerbations.
most commonly associated with amiodarone toxicity?
Fatigue, weight gain, and constipation are classic signs and symptoms of hypothyroidism
Fibrates (etc gemfibrozil) side effect?
Cholesterol gallstones and Myoglobinuria
Niacin side effect
What causes peaked T waves and widened PR intervals. Name a drug
Hyperkalemia - Spironolactone
Drug that blocks α1-, α2-, and β1-receptors.
Fibrates act via
Fibrates stimulate synthesis of lipoprotein lipase by activation of the PPAR-α protein. In turn, lipoprotein lipase increases hydrolysis of triglycerides and VLDL, which ultimately results in decreased triglyceride and LDL levels
Peroxisome proliferator-activated receptors
Niacin decreases? Increases? (Specifically for lipid levels)
Reduced hepatic triglyceride and VLDL synthesis. Increase HDL
How does Adenosine stop AV arrhythmias?
Adenosine works by hyperpolarizing AV node tissue by increasing the conductance of potassium and by reducing calcium current.
Treat hypotension due to septic shock
an antiarrhythmic agent known to cause drug-induced lupus
COX 2 inhibitor decreases?
Decreases PGI2, TXA2 normal
Digoxin and furosemide
may induce a life-threatening arrhythmia
Angioedema - side effect of
What is a common heart physiologic effect of norepinephrine?
Decrease in heart rate
Common side effects - Thiazides
hyperGLUC (Glycemia, Lipidemia, Uric acid, Calcium.)
β-Blockers work by
inhibiting the G-protein/cyclic adenosine monophosphate (cAMP) mechanism. β-Blockers cause a decrease in Na+ and Ca2+ currents
Among antihypertensive agents, the only widely available transdermal (or "patch") medication for lowering blood pressure is