Care Questions

Question 1

In addition to losartan which other commonly used medications increases urinary excretion of uric acid and therefore prevents gout in diabetic patients

Answer 1

SGLT-2 inhibitors

Question 2

Which proximal tubular transporter does uric acid and glucose compete for and hence result in increased uric acid excretion by SGLT-2

Answer 2

GLUT9b

Question 3

Which gene that encodes for a major renal and extra renal transporter of uric acid is implicated in pathogeneses of gout

Answer 3

ATP binding cassette subfamily G member 2 (ABCG2)

Question 4

What are the two major ways uric acid is excreted from the body

Answer 4

Gut and kidney

Question 5

When should you suspect a partial HGPRT deficiency in a gout patient

Answer 5

Major manifestations: gout, nephrolithiasis or asymptomatic hypertutecemia

+

Neurological issues - dystonia, OCD

Question 6

What are the 2 inborn errors of metabolism that lead to gout — both are X linked and therefore should not be seen in girls

Answer 6

1. HGPRT
2. PRPP

Question 7

Gene mutations for CPPD

Answer 7

Progressive ankylosis protein homolog (ANKH)