Category A toxins Flashcards Preview

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Flashcards in Category A toxins Deck (12):
1

Anthrax

Mode of transmission: edospores enter body through abraisions, inhalation, or ingestion (GI) - person to person except for inhalation

Incubation period 1 week up to 2 months

Case fatality 100%

Treatment options: antibiotics (vaccine available in labs and military bases)

2

Botulism

Mode of transmission: food-borne, infant, and wound all occur naturally; inhalation is not naturally occurring NOT spread person to person

Incubation period: 12-36hours, (rarely 6hr-10days)

Case fatality: 5-10%

CNS depression, dilated or non-reactive pupils, dropoping face, weakness, paralysis, but intact mental state and sensory system, no fever

Tx: antitoxin, supportive care NO VACCINE

3

Small Pox

Mode of transmission: person to person (contact and droplet)

Incubation period: 12-14 days

Case fatality ~30%

Treatment opportunity: no treatment, vaccine available

4

Tularemia

Mode of transmission: NOT spread person to person; multiple sources including insect bites, handling ill/dead animals, lab accidents; can live in soil for weeks, airborne is naturally occurring exposure (but rare)

Incubation period: 1-14 days (3-5 typically)

Case fatality ~2%

Treatment: antibiotics (NO VACCINE)

5

Pneumonic plague

Mode of transmission: bacteria found in rodents and their fleas; spread person to person through droplet (non-aerosolized = bubonic plague) rarely occurs naturally

Incubation period: 1-3 days

Case fatality: 5-10%

Tx: antibiotics (vaccine available but efficacy unknown)

6

Viral hemorrhagic fever

Mode of transmission: naturally occurring, spread person to person (contact)

Incubation period: 2-21 days (avg 8-10 days)

Case fatality rate: 40-50%

Treatment opportunity: supportive, no treatment or vaccine

7

Which have fever?

All except botulism

8

Which have chest discomfort?

Anthrax and plague

9

Which have cough?

Anthrax, plague, Tularemia

10

Which have myalgia (pain in muscles)?

Anthrax, Tularemia, small pox, VHF

11

Which have weakness/malaise?

All except botulism

12

Which have paralysis

only botulism