Flashcards in cell communication 4 Deck (12):
What are the six classes of enzyme coupled receptors?
RTKs - tyrosine activity
Tyrosine -kinase -associated receptors - associated with tyrosine kinase
Receptor serine threonine kinases- receptor serine/threonine kinase
receptor guanyll cyclases - guanyl cyclase activity
What are the signal molecules of RTKs?
growth factors and hormone families
What activates RTKs?
ligand binding causes dimerization of RTKs and cross phosphorylation of tyrosine residues- trans autophosphorylation
this enhances activity
What does mutant tyrosine domains cannot do?
What does phosphorylated tyrosine's serve as?
docking sites for intracellular signaling proteins
What does SH2 domains bind to?
How does RTKs activate ras?
through adaptors and GEFs
Which GTPases regulate cytoskeleton?
What does ras activate?
Map kinase signaling
What does full activation of MAPK require?
phosphorylation of both threonine and tyrosine
What does an active MAP K do?
phosphorylates several proteins including gene regulatory proteins and other protein kinases
Mapk genes are called immediate early genes