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Flashcards in cell communication 4 Deck (12):
1

What are the six classes of enzyme coupled receptors?

RTKs - tyrosine activity
Tyrosine -kinase -associated receptors - associated with tyrosine kinase
Receptor serine threonine kinases- receptor serine/threonine kinase
receptor guanyll cyclases - guanyl cyclase activity

2

What are the signal molecules of RTKs?

growth factors and hormone families

3

What activates RTKs?

ligand binding causes dimerization of RTKs and cross phosphorylation of tyrosine residues- trans autophosphorylation
this enhances activity

4

What does mutant tyrosine domains cannot do?

dimerize

5

What does phosphorylated tyrosine's serve as?

docking sites for intracellular signaling proteins

6

What does SH2 domains bind to?

phosphorylated tyrosines

7

How does RTKs activate ras?

through adaptors and GEFs

8

Which GTPases regulate cytoskeleton?

RHO family

9

What does ras activate?

Map kinase signaling

10

What does full activation of MAPK require?

phosphorylation of both threonine and tyrosine

11

What does an active MAP K do?

phosphorylates several proteins including gene regulatory proteins and other protein kinases
Mapk genes are called immediate early genes

12

What does PI3k do?

phosphorylates inositol phospholips
can be activated by RTKs and GPCR and other receptors

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