Cell Cycle Nonspecific Drug Tables - Fitz Flashcards Preview

Heme/Lymph 2 > Cell Cycle Nonspecific Drug Tables - Fitz > Flashcards

Flashcards in Cell Cycle Nonspecific Drug Tables - Fitz Deck (26):
1

Dacarbazine, Procarbazine, Temozolomide - function

Methylate guanosine at O6, N7 - causing DNA miscoding and damage

2

Dacarbazine use

Metastatic melanoma

3

Procarbazine use

Malignant glioma

4

Temozolomide uses

Resistant glioma, astrocytoma

5

Carmustine, Lomustine - function

Alkylate guanosine at O6, N7 - causing DNA miscoding and damage

6

Carmustine, Lomustine - uses

Brain tumors, lymphoma, melanoma

7

Streptozocin function

Beta cell islet destruction

8

Streptozocin use

Insulinoma

9

Streptozocin toxicity

Diabetes

10

Cyclophosphamide, Ifosfamide - function

Crosslinks DNA

11

Mechlorethamine use

MOPP regimen (lymphoma)

12

Melphalan use

Multiple myeloma

13

Chlorambucil use

CLL

14

Busulfan use

CML

15

Melphalan, Chlorambucil, Busulfan - function

Crosslinks DNA

16

Thiotepa, Mitomycin C, Altretamine - function

DNA G-G crosslinks

17

Thiotepa uses

Breast, ovarian, bladder

18

Mitomycin C uses

Breast, GI

19

Altretamine use

Recurrent/resistant ovarian

20

Cisplatin, Carboplatin, Oxaloplatin - function

Platinum-Cl conversion to Platinum-H2O, which disrupts DNA

21

Cisplatan uses

Testicular (w/ bleomycin, vinblastine/etoposide), ovarian, NSCLC

22

Carboplatin use

Ovarian

23

Oxaloplatin

Colorectal (FOLFOX regimen)

24

Cisplatin toxicities

Renal disease, ototoxicity, N/V

25

Carboplatin toxicity

Neutropenia

26

Oxaloplatin toxicities

Neutropenia, cold-induced neuropathy