Flashcards in Cell Injury Deck (12):
List the eight causes of cell injury.
1) Oxygen deprivation
3) Chemical agents
6) Nutrient imbalances
7) Physical agents
What four intracellular mechanisms are particularly vunerable to injury?
Cell membrane integrity
Genetic apparatus integrity
Shrinking cell or organ size due to loss of cell substance.
Increase in cell size, organ grows due to this.
Confluent cell death associated with inflammation.
Describe some uses of apoptosis.
Removal of self reactive lymphocytes
Cell deletion in proliferating population
Embryogenesis - lumen formation in intestine.
Describe three differences between apoptosis and necrosis.
Apoptosis requires energy (active)
Apoptosis can be physiological
Apoptosis not associated with inflammation
Pre-cancerous cells which show the genetic and cytological features of malignancy but not invading underlying tissue.
What are the two physiological causes of hyperplasia?
Hormonal e.g. Oestrogens to endometrium
What are two light microscopic changes associated with reversible cell injury?
What are the four types of necrosis?