Cell Injury Flashcards Preview

MCD Cell Pathology > Cell Injury > Flashcards

Flashcards in Cell Injury Deck (12):
1

List the eight causes of cell injury.

1) Oxygen deprivation
2) Inflammation
3) Chemical agents
4) Genetics
5) Infection
6) Nutrient imbalances
7) Physical agents
8) Ageing

2

What four intracellular mechanisms are particularly vunerable to injury?

Cell membrane integrity
Protein synthesis
ATP generation
Genetic apparatus integrity

3

Define atrophy

Shrinking cell or organ size due to loss of cell substance.

4

Define hypertrophy

Increase in cell size, organ grows due to this.

5

Define Necrosis

Confluent cell death associated with inflammation.

6

Describe some uses of apoptosis.

Removal of self reactive lymphocytes
Cell deletion in proliferating population
Embryogenesis - lumen formation in intestine.

7

Describe three differences between apoptosis and necrosis.

Apoptosis requires energy (active)
Apoptosis can be physiological
Apoptosis not associated with inflammation

8

Define dysplasia

Pre-cancerous cells which show the genetic and cytological features of malignancy but not invading underlying tissue.

9

What are the two physiological causes of hyperplasia?

Hormonal e.g. Oestrogens to endometrium

Compensatory

10

What are two light microscopic changes associated with reversible cell injury?

Fatty change
Cellular swelling

11

What are the four types of necrosis?

Fat
Caseous
Liquefactive
Coagulative

12

What disease is fat necrosis associated with and why?

Acute Pancreatitis - lipases released, so TAGs broken down to FFAs and glycerol. Associate with Ca deposits.