Cell Injury Flashcards
Weissman
Two key events in Extrinsic Apoptosis
- Fas/TNF Ligand binding
2. Caspase cascade
Growth factor withdrawal, DNA damage, or Protein misfolding causes _____ Apoptosis to occur
Intrinsic
Low survival signals, DNA damage, and protein damage are red flags to start the irreversible _____
Apoptosis
Metaplasia
A reversible Change whereby an adult cell type is replaced by another.
Three key events in Intrinsic Apoptosis
- Bax and Bak are activated
- Bcl-2 is inhibited
- Cytochrome C activated Caspase
After an infection is over, lymphocytes typically use the _____ pathway of apoptosis
Extrinsic
In the irreversible cell damage, Shrinkage usually means _____ is occurring, whereas swelling means ____ is occurring
Necrosis
Calorie restriction activates the molecules known as _____ to protect DNA damage
Sirtuins
Two Earliest Reversible Cell injury changes are:
- Decreased ATP
2. Cell Swelling
In _____ Necrosis, the underlying tissue architecture is preserverd
Coagulative
Nuclear Fading, Shrinkage, Fragmentation, and Lysosomal rupture are signs of the Irreversible Cell damage konwn as _____
Necrosis
TNFR1 is the ligand for the cell-damage process of ______
Necroptosis
Metastatic Calcification occurs in _____ tissues and is associated with Hypercalcemia
Normal
Morphologically looks like necrosis, but genetically programmed like apoptosis is _____
Necroptosis
_____ Necrosis has tissue architecture obliterated and is surrounded by a granuloma
Caseous
