Cell surface proteins, effects of bacterial toxins, antigenic variation

Question 1

Which cells express MHC-I

Answer 1

All nucleated cells except mature RBCs

Question 2

Cell surface protein located on T-cell binds antigen-MHC complex

Answer 2

TCR

Question 3

Cell surface protein located on T-cell and associated with TCR for signal transduction

Answer 3

CD3

Question 4

Cell surface protein located on T-cell and binds B7 on APC

Answer 4

CD28

Question 5

Cell surface protein located on T-cell and function as co-receptors for HIV

Answer 5

CXCR4/CCR5

Question 6

Cell surface protein located on helper T-cells

Answer 6

CD4, CD40L

Question 7

Cell surface protein located on cytotoxic T-cells

Answer 7

CD8, CXCR4/CCR5

Question 8

Cell surface protein located on T-regs

Answer 8

CD4, CD25

Question 9

Cell surface protein located on B-cells and binds antigen

Answer 9

Ig

Question 10

Cell surface protein located on B-cell and receptor for EBV

Answer 10

CD21

Question 11

Cell surface protein located on B-cell

Answer 11

CD19, CD20, CD21, CD40, MHC-II, B27

Question 12

Cell surface protein located on B-cell and binds with CD28 on T-cells

Answer 12

B27

Question 13

Cell surface protein located on macrophages and binds with bacterial PAMPs

Answer 13

CD14

Question 14

A type of bacterial PAMP that binds with CD14

Answer 14

LPS

Question 15

Cell surface proteins located on macrophages

Answer 15

CD14, CD40, CCR5, MHC-II, B7, Fc and C3b receptors

Question 16

Cell surface proteins located on macrophages that enhance phagocytosis

Answer 16

Fc and C3b receptors for antibodies and opsonins, respectively

Question 17

NK cell surface protein marker

Answer 17

CD56

Question 18

Hematopoietic stem cell surface protein marker

Answer 18

CD34

Question 19

State when cell cannot be activated when exposed to its antigen

Answer 19

Anergy

Question 20

T and B cells become anergic when exposed to antigen without…

Answer 20

second costimulatory signal

Question 21

Toxin that cross-liinks the beta-region of the T-cell receptor to the MHC-II on APCs

Answer 21

Superantigens from S pyogenes and S aureus

Question 22

Superantigens that activate CD4+ T-cells cause…

Answer 22

massive release of cytokines

Question 23

Toxins that directly stimulate macrophages by binding to TLR4/CD14 receptors

Answer 23

Endotoxins, LPS (gram-negative bacteria)

Question 24

Bacteria with antigenic variation

Answer 24

Salmonella, Borrelia recurrentis, N gonorrhea

Question 25

Viruses with antigenic variation

Answer 25

HIV, HCV, influenza

Question 26

Parasites with antigenic variation

Answer 26

Trypanosomes

Question 27

Influenza virus mechanism for antigenic variation involving DNA rearrangement and RNA segment reassortment

Answer 27

Influenza major shift

Question 28

Influenza virus mechanism involving protein mutation

Answer 28

Influenza minor shift

Question 29

Salmonella has what type of antigenic variation

Answer 29

2 flagellar variants

Question 30

Borrelia recurrentis has what type of antigenic variation

Answer 30

Relapsing fever

Question 31

N gonorrhea has what type of antigenic variation

Answer 31

Pilus protein