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Bio Module 6 > Cellular Control > Flashcards

Cellular Control Flashcards

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1
Q

Where is mRNA made?

A

mRNA is made in the nucleus

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2
Q

What bases does mRNA contain?

A

Adenine, guanine, uracil and cytosine

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3
Q

What does universal mean when referring to properties of the genetic code?

A

The same codons code for the same amino acids in all organisms

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4
Q

What does degenerate mean when referring to the properties of the genetic code?

A

Most amino acids have more than one codon that code for them

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5
Q

What does non-overlapping mean when referring to properties of the genetic code?

A

Each base is only read once

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6
Q

What are the 4 types of genes?

A

Structural genes
Regulatory genes
Housekeeping genes
Tissue specific genes

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7
Q

What are structural genes?

A

Genes that code for a protein that has a function within a cell.

Eg. Genes coding for enzymes, membrane carriers, hormones etc.

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8
Q

What are regulatory genes?

A

Genes that code for proteins (or various forms of RNA) that control the expression of structural genes

Eg. Genes coding for transcription factors

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9
Q

What are housekeeping genes?

A

Genes that code for proteins that are constantly required

Eg. Genes that code for enzymes necessary for reactions in respiration

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10
Q

What are tissue specific genes?

A

Genes that code for proteins that are only required at certain times to carry out a short-lived response

Eg. Genes coding for hormones used for growth and repair

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11
Q

What are the 4 different ways genes can be regulated?

A

Transcriptional
Post-transcriptional
Translation
Post-translational

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12
Q

How are genes regulated at transcriptional level?

A

Genes are able to be turned on/off

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13
Q

How are genes regulated at post-transcriptional level?

A

mRNA can be modified, which regulates translation and the types of proteins produced

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14
Q

How can genes be regulated at translational level?

A

Translation can be stopped or started

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15
Q

How can genes be regulated at post-translational level?

A

Protein can be modified after synthesis, which changes their function

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16
Q

What are heterochromatin?

A

Tightly wound DNA —> Chromosomes are visible under a microscope

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17
Q

What are Euchromatin?

A

Loosely wound DNA —> Not visible under a microscope

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18
Q

Transcription isn’t possible when DNA is tightly wound (heterochromatin). Why?

A

Because RNA polymerase can’t attach and move along the DNA

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19
Q

During what part of the cell cycle does protein synthesis take place?

A

During the interphase because there is euchromatin, making genes more accessible to RNA polymerase

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20
Q

What charge does DNA have?

A

DNA has a negative charge

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21
Q

What charge do histone proteins have?

A

A positive charge

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22
Q

What happens at acetylation and phosphorylation?

A

•Reduce charge on histone
•Histones now become more negative
•Causing DNA to coil less tightly
•Genes are now more accessible

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23
Q

What happens during methylation of histone proteins?

A

• Involved adding a hydrocarbon
• Histones now more hydrophobic
• The histone bind tighter together
• DNA coils tighter as a result
• This prevents transcription of genes

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24
Q

What are epigenetics?

A

Heritable changes in gene function that don’t change the base sequence of DNA

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25
What are examples of epigenetics?
Acetylation Phosphorylation Methylation
26
Which part of the gene do transcription factors bind to?
The promoter region
27
What are activators?
The binding of the transcription factor aids RNA polymerase binding to DNA, starting transcription
28
What are repressors?
The binding of the transcription factor blocks RNA polymerase from binding to DNA, stopping transcription
29
What are tumour suppressor genes?
Genes that inhibit proliferation and tumour development. They stop cells from dividing too quickly
30
What are protooncogenes?
Genes involved in normal cell growth, which if mutated, it may become an oncogene which can cause cancer
31
What is a transcription factor?
Proteins that bind to DNA and control which genes in a cell are turned on and off
32
Where do transcription factors bind in eukaryotic gene expression?
They bind to the promoter region
33
What is an operon?
A group of genes under the same regulatory mechanism that are expressed at the same time
34
E. Cool prefer glucose as a respiratory substrate. If this is in short supply what do they use instead? And what are the drawbacks?
If glucose is unavailable they will use lactose. However different enzymes are required to metabolise lactose
35
What protein does the gene Lac Z in E. coli code for?
Lac Z codes for the protein B- galactosidase. The function of beta galactosidase is to hydrolyse lactose to glucose and galactose
36
What protein does the gene Lac Y in E. coli code for?
Lac Y coded for the protein lactose permease which facilitates the crossing of lactose across the cell membrane
37
What is the role of Lac I?
Lac I is a regulatory gene located near the operon. Lac I codes for a depressor protein that is constantly being made and prevents the transcription of Lac Z and Lac Y in the absence of lactose
38
What is a phosphodiester bond?
The covalent bond between the sugar of one nucleotide and the phosphate of the next nucleotide
39
What is a mutation?
The change in a sequence of bases in DNA
40
What are the 3 types of mutation?
Substitution Deletion Insertion
41
What is a substitution mutation and what are they also known as?
A substitution mutation is when one nucleotide is substituted for another Also known as point mutations
42
What are the 3 types of point mutation?
Silent mutation - different codon but same amino acid Missense mutation - different amino acid Nonsense mutation - stop codon
43
What is an insertion mutation?
An insertion mutation is when an extra nucleotide is added
44
What is a deletion mutation?
A mutation when a nucleotide is removed
45
What are insertion and deletion mutations know as?
Frame shift mutations These are generally worse than substitution mutations
46
What is a neutral effect of a mutation?
Normal functioning protein is still synthesised - phenotype of organism is unchanged
47
What is a harmful effect of a mutation?
The protein is not synthesised or is non-functional. The phenotype of the organism is negatively impacted
48
What is a beneficial effect of a mutation?
The protein is synthesised with a new and useful characteristic in the phenotype
49
What are the 4 types of chromosome mutations?
Deletion - section breaks off Duplication - section duplicated Translocation- section breaks off and rejoins another non-homologous chromosome Inversion- section breaks off, is reversed and joins back on
50
What is a body plan?
The structure of an organism
51
Name the genes that control the development of a body plan
Homeobox genes
52
Why is development of body plans similar for plants, animals and fungi?
It is controlled by similar homeobox genes in each type of organism. The homeobox genes have highly conserved region called the homeobox
53
What are homeotic genes?
Genes that regulate morphogenesis (the process that causes an organism to form its shape)
54
What is a homeobox gene?
A subset of homeotic genes which contain a homeobox sequence
55
What is a homeobox sequence?
A sequence of 180 base pairs found within homeobox genes which are involved in regulating anotomical development in plants and fungi. It is highly conserved
56
What is a homeodomain sequence?
60 amino acids found in all homeobox protein (encoded by the homeobox sequence) It is part of the protein that binds to DNA, allowing the protein to act as a TF to activate or repress genes.
57
What are hox genes?
A subset of homeobox genes found only in animals. It is involved in the formation of anatomical features in the correct location of the body plan. They code for homeodomain proteins
58
Give examples of how genes controlling development of a particular segment of the body plan?
Hox genes in the head control the development of mouth parts. Hox genes in the thorax control the development of wings, limbs, ribs
59
What are diploblastic animals?
Animals that have 2 primary tissue layers in the developing embryo Eg. Jellyfish, corals, sea anemones
60
What are triploblastic animals?
Animals that have 3 primary tissue layers in the developing embryo Eg. More complex animals from worms to humans
61
What is colinearity?
The order in which genes appear along the chromosomes is which their effects are expressed in an organism
62
What do hox genes regulate?
The development of embryos along the anterior —> posterior axis (head —> tail) and they are responsible for correct positioning of body parts
63
What does highly conserved mean?
Meaning the sequence is kept through evolution and is the same for many different organisms
64
What is morphogenesis?
The regulation of the pattern of anatomical development
65
What is apoptosis?
Programmed cell death. It is regulate by hox genes and is deliberate and controlled
66
What is apoptosis?
Programmed cell death. It is regulate by box genes and is deliberate and controlled
67
What are internal stimuli that result in apoptosis?
Damage to DNA - prevents uncontrolled cell division Release of hormones Psychological stress
68
What are external stimuli that can cause apoptosis?
Changes in light intensity Disease Lack of nutrients Effects of drugs eg. Thalidomide
69
What are the stages of apoptosis?
1) enzymes break down cell cytoskeleton 2) the cytoplasm becomes densely packed with organelles. The cell surface membrane changes and ‘blebs’ form 3) chromatin condenses, the nuclear envelope breaks down, and DNA breaks into fragments 4) The cell breaks into vesicles that are then ingested by phagocytes so that cell debris doesn’t damage other cells or tissue

Bio Module 6 (3 decks)

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