Cellular Immune Response Flashcards Preview

Pathology-IMED4111 > Cellular Immune Response > Flashcards

Flashcards in Cellular Immune Response Deck (10):
1

What are 4 cellular immune responses to pathogens?

1. Lysis of infected cells by cytolytic lymphocytes
2. Activation of monocytes and macrophages
3. Activation of neutrophils and eosinophils
4. Granuloma formation to contain the infection

2

What is the innate and adaptive mechanisms for the cellular response: Lysis of infected cells by cytolytic lymphocytes?

Innate: Natural Killer Cells

Adaptive: CD8+ T-cells

3

What is the innate and adaptive mechanisms for the cellular response: Activation of monocytes and macrophages?

Innate: Directly via PRRs

Adaptive: IFNgamma from CD4+ T-cells

4

What is the innate and adaptive mechanisms for the cellular response: Activation of neutrophils and eosinophils?

Innate: Directly via PRRs

Adaptive: IL-17 and IL-22 from CD4+ T-cells

5

What is the innate and adaptive mechanisms for the cellular response: Granuloma formation to contain the infection

Innate: N/A

Adaptive: IFNgamma from CD4+ T-cells

6

What types of invasive candida infections can you get?

• Acute mucocutaneous infecDon
• Chronic mucocutaneous candidiasis
• Systemic candidiasis
– Skin
– Eye
– Liver and spleen
– Kidney

7

What are the immune evasion strategies of Candida albicans?

- Inhibition of complement activation and complement receptor function
- inhibition of phagocytosis by macrophages
- inhibition of intracellular killing mechanisms in macrophages
- inhibition of pro-inflammatory cytokines AND secretion of anti-inflammatory cytokines

8

What causes the antigenic variation of HIV that allows it to evade the immune system?

- high mutation rate
- lots of recombination

9

How does a tuberculin skin test work?

It tests the CD4 T-cell response. It is a delayed type hypersensitivity response to tuberculin. If you have CD4 cells that recognise the bacteria then you will get an active response.

10

How does Mycobacterium tuberculosis evade macrophages?

- Interference with phagosome function
- inhibition of inflammasome activation
- induction of macrophage necrosis

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