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Flashcards in Cellular Reaction To Injury Deck (42):
1

Intracytoplasmic vacuoles containing debris from degraded organelles seen in atrophy

Autophagic granules

2

Formation of new bone at sites of tissue injury

Osseous metaplasia

3

Proliferation of hematopoietic tissue at siyes other than the bone marrow

Myeloid metaplasia (extramedullary hematopoiesis)

4

Whorl-like structures originating from damaged membranes which is a reversible morphologic sign of hypoxic cell injury

Myelin figures

5

A cell surface deformity due ti disorderly function of the cellular cytoskeleton which is a reversible morphologic signs of hypoxic cell injury

Cell blebs

6

Hypoxic injury becomes irreversible after how many minutes for neurons

3-5

7

Hypoxic injury becomes irreversible after how many hours for myocardial cells and hepatocytes

1-2

8

Ocular disorder of premature infants which is due to oxygen toxicity

ROP or retrolental fibroplasia

9

Proliferation and hypertrophy of the SER of the hepatocyte are classic ultrastructural markers of:

Barbiturate toxicity

10

Type of necrosis that resukts from sudden cutoff of blood supply to an organ

Coagulative necrosis

11

Necrosis characterized by general preservation of tissue architecture

Coagulative necrosis

12

Morphologic hallmark of irreversible cell injury and necrosis

Nuclear changes

13

Nuclear change characterized by chromatin clumping and shrinking with increased eosinophilia

Pyknosis

14

Nuclear change characterized by fragmentation of chromatin

Karyorrhexis

15

Nuclear change characterized by fading of chromatin material

Karyolysis

16

Type of necrosis in the inschemic injury of CNS and in suppurative infections

Liquefactive necrosis

17

Necrosis that occur as part of granulomatous inflammation

Caseous necrosis

18

Leading cause of caseous necrosis

Tuberculosis

19

Necrosis that is characterized by cheese-like consistency

Caseous necrosis

20

Necrosis that is histologically characterized by amorphous eosinophilic appearance

Caseous necrosis

21

Type of necrosis that most oftenly occur at the lower extremities and bowel

Gangrenous necrosis

22

Type of gangrene that is complicated by infective heterolysis and consequent liquefactive necrosis

Wet gangrene

23

Type of gangrene that is characterized by coagulative necrosis without liquefaction

Dry gangrene

24

Deposition of fibrin-like proteinaceous material in the arterial walls

Fibrinoid necrosis

25

Occurs aftwr a severe injury to tissue with high fat content such as the breast

Traumatic fat necrosis

26

Aspartate-specific cyateine proteases that have been referred to as "major executioners" or "molecular guilotines"

Caspases

27

Initial activating caspases

Caspase-8 and 9

28

Terminal or executioner caspases

Caspase-3 and 6

29

Gene product that inhibits apoptosis

Bcl-2

30

Gene product that facilitates apoptosis

Bax

31

Gene product that decreases transcription of bcl-2 and increases transcription of bax thereby facilitating apopotosis

P53

32

Accumulation of intracellular parenchymal triglycerides

Fatty change (usually seen in liver, heart and kidney)

33

Lead poisoning

Plumbism

34

Silver poisoning

Argyria (cause permanent gray discoloration of the skin and conjunctiva)

35

Melanin is formed from:

Tyrosine (by the tyrosinase)

36

Potentially reversible change that often precedes malignancy

Dysplasia

37

Neoplasm that has close resemblance to tissue of origin

Well-differentiated

38

Neoplasm that has little resemblance to the tissue of origin

Poorly differentiated

39

Most important definibf characteristic of malignancy

Metastasis


(But some such as basal cell carcinoma of the skin rarely metastasize)

40

Tumor cells are very poorly differentiated, with pleomorphism, hyperchromatism, increased N:C ratio, abnormal mitosis, cellular dyspolarity and prominent nucleoli

Anaplasia


Common feature of malignancy

41

True or False: most aggressive tumors often respond well to chemotherapy and radiotherapy

Yes. These are most effectove with rapidly dividing cells

42

Malignant tumor of epithelial origin

Carcinoma