Cellular Receptors Flashcards Preview

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Flashcards in Cellular Receptors Deck (16):
1

Types of binding domains of plasma membrane receptors

Ligand-Gated Ion-channel receptors. Enzyme-linked receptors. Cytosine receptors. G-protein coupled receptors.

2

Nicotinic Acetylcholine receptor

Binding of acetylcholine creates conformational changes to allow Na to diffuse in and K to diffuse out. this creates contraction of the fiber in the cell

3

Tyrosine Kinase Receptors

Growth factor bind to the receptor to promote dimerization. Intracellular domains of receptor phosphorylates on certain resides. This creates binding sites for signal transducer proteins

4

Serine-Threonine Kinase Receptors

Used in proteins in the transforming growth factor superfamily. Phosphorylates serine or threonine. Associated with gene transcription factors (β transforming growth factor regulation/proliferation)

5

Tyrosine Kinase-Associated Receptors

Usually used by growth hormone and prolactin. Binds to JAK kinase factors.

6

What do JAK kinase factors phosphorylate?

a tyrosine residue on STATs

7

What do STAT-Ps do?

Enter the nucleus and activate transcription by binding to specific response elements. Activate immune responses and inflammation.

8

G-Protein Receptor

Nucleotide regulatory proteins that link to intracellular secondary messengers

9

Examples of secondary messengers

cAMP, cGMP, Ca, DAG, phospyatidylinositides

10

Lipophilic hormone receptors

Intracellular receptors

11

Cytosolic receptors

Type of lipophilic hormone intracellular receptor. bound to heat shock proteins. Binding of hormone causes complex to migrate to the nucleus, where it can create positive or negative transcription.

12

Nuclear receptors

Type of lipophilic hormone intracellular receptor. Found in the nucleus with NO HSP. Hormone binding creates conformational changes that lead to positive or negative transcription.

13

Ligand

Chemical that binds with high specificity to a receptor

14

Graves' Disease

Antibodies against thyroid stimulating hormone receptors

15

Myasthenia Graves

Antibodies against nicotinic acetylcholine receptors

16

JAK-STAT transcription factors are stimulated by what?

Cytokines