Cephalosporin coverage

Question 1

1st gen

Answer 1

gm +
gm + anaerobes
PEK

mostly preferred for MSSA

Question 2

2nd gen

Answer 2

gm +
HNPEK
gm + anaerobes

ONLY cefotetan and cefoxitin cover B. fragilis

Question 3

3rd gen group 1

Answer 3

gm + (more resistant strep pneumo & strep viridans)
more resistant HNPEK
gm + anaerobes

Question 4

3rd gen group 2

Answer 4

ceftazidime has little gm + activity
HNPEK
pseudomonas

beta-lactamase inhibitor combos have extended MDR gm- rod coverage including pseudomonas

Avycaz covers CRE

Question 5

4th gen

Answer 5

HNPEK
CAPES
pseudomonas
gm + (resistant strep pneumo and strep viridans)
gm + anaerobes

Question 6

5th gen

Answer 6

broadest gm + activity including MRSA
no pseudomonas coverage
more resistant HNPEK