Cephalosporins

Question 0

T/F each succeeding generation is more effective against g negative bacteria and broader spectrum of activity

Answer 0

T, 4th gen has broadest spectrum

Question 1

Cephalosporins not active against

Answer 1

L. monocytogenes

Enterococci

Question 2

Cefazolin

Answer 2

1st gen

Question 3

Cephalothin

Answer 3

1

Question 4

Cephalexin

Answer 4

1

Question 5

Cephradine

Answer 5

1

Question 6

Cefadroxil

Answer 6

1

Question 7

Cefaclor

Answer 7

2

Question 8

Cefamandole

Answer 8

2

Question 9

Cefonicid

Answer 9

2

Question 10

Cefuroxime

Answer 10

2

Question 11

Cefprozil

Answer 11

2

Question 12

Loracarbef

Answer 12

2

Question 13

Ceforanide

Answer 13

2

Question 14

Cefixime

Answer 14

3

Question 15

Moxalactam

Answer 15

3

Question 16

Ceftriaxone

Answer 16

3

Question 17

Cefotaxime

Answer 17

3

Question 18

Cefepime

Answer 18

4

Question 19

Gram positive cocci

Answer 19

Pneumococci
Streptococci
Staphylococci

Question 20

Cross allergenicity more common compared to other generations

Answer 20

1st

Question 21

The only first gen cephalosporin still in use

Answer 21

Cefazolin

Question 22

2nd gen extension, organisms?

Answer 22

Klebsiella
H. influenza
B. fragilis
M. catarrhalis
N. gonorrhea
N. meningitides

Question 23

2nd gen cephalosporin that can cross the BBB

Answer 23

Cefuroxime

Question 24

3rd gen with useful activity against P. aeruginosa

Answer 24

Ceftazidime | Cefoperazone

Question 25

Used as empirical therapy of sepsis of unknown cause in immunocompromised and immunocompetent patients

Answer 25

3rd gen cephalosporins

Question 26

Reduced effects against staph but same activity against strep

Answer 26

Ceftriaxone

Question 27

Iv/im cns and genitourinary infections Bone and joint infections Skin and soft tissue infections Mild community acquired respiratory infections

Answer 27

Ceftriaxone

Question 28

Adverse effect: biliary sludge

Answer 28

Ceftriaxone

Question 29

Has longest half life among 3rd gen

Answer 29

Ceftriaxone

Question 30

Goo activity against P. aeruginosa

Answer 30

Cefepime

Question 31

LRTs UTI Skin and soft tissue infections Intra abdominal infections

Answer 31

Cefepime

Question 32

Most stable against beta lactamases produced by gram negative bacteria

Answer 32

Cefepime

Question 33

Pref for nosocomial infections and those caused by enterobacteriaceae

Answer 33

Cefepime

Question 34

Ceftriaxone administration

Answer 34

IM | IV

Question 35

Cefepime admin

Answer 35

IV

Question 36

Cefuroxime admin

Answer 36

IV | Oral

Question 37

Cefazolin admin

Answer 37

IM | IV

Question 38

``` Alternative for antistaph penicillin Surgical and endocarditis prophylaxis Bone and joint infections Pharyngitis Community acquired UTIs ```

Answer 38

Cefazolin

Question 39

Kidney failure | Hemolytic anemia are effects of

Answer 39

Cefazolin

Question 40

Community acq uti and rti Bone and joint infections Skin and soft tissue infections

Answer 40

Cefuroxime