Ch 11 Flashcards Preview

immunology > Ch 11 > Flashcards

Flashcards in Ch 11 Deck (29):
1

witebsky's postulates

1. autoimmune response must be regularly associated with the disease
2. disease must be inducible in lab animals
3. natural and experimental disease should be pathologically similar
4. transfer of disease to normal individual with serum or immunocompetent cells

2

molecular mimicry

microbes that cause cross-reactive antibodies

3

autoimmune therapy

steroids
immunosuppression
NSAIDs (anti-inflammatory)

4

monoclonal Ab for crohns and rheumatoid arthritis

anti TNF-alpha

5

monoclonal Ab for psoriasis

anti-IL 12/23
anti-CD11a (not used in US anymore)

6

monoclonal Ab for MS

anti-alpha4 integrin

7

monoclonal Ab for systemic lupus

anti-BLyS

8

thyroid autoimmune diseases

Hashimoto's and Grave's

9

dry eyes and mouth
connective tissue, joints

sjogren's disease

10

mostly females
connective tissue, joints
male fetal cells in circulation

scleroderma

11

inflammation of colon
high Ab titers for E coli and bacteriodes
granulomas

Crohn's disease

12

95% have HLA-B27
more males
fusion of lumbar spine

ankylosing spondylitis

13

Ab to major myelin protein
TH17 and TH1 cells involved
demyelination of neural tissue

MS

14

Ab for adrenocortical cells of adrenal glands
prone to infections

Addison's

15

Ab to glomerular and long basement membranes collagen type IV
kidney failure and lung involvement
organic solvents and HLA-DR2

Goodpasture's syndrome

16

Ab to acetylcholine R
flaccid muscles, progressive weakness

Myasthenia Gravis

17

Ab to intrinsic factor for uptake of vitamin B12

Pernicious anemia

18

Ab to RBCs
cold stress test, loss of blood flow to fingers

Raynaud's

19

Ab to blood group Ag
Drug-induced anemia

autoimmune hemolytic anemia

20

Ab that stimulate thyroid production
high thyroid function

Grave's disease

21

low thyroid function
IgG and IgM anti-thyroglobulin
Fas on all thyroid cells
apoptosis

Hashimoto's

22

-omab

fully mouse mAb

23

-ximab

chimeric mAb

24

-zumab

humanized mAb

25

-umab

fully human mAb

26

formation of immune complexes in joints
accumulation in synovial joins

Rheumatoid arthritis

27

treatment for Rheumatoid arthritis
and effective for Crohn's

Anti-TNF therapy

28

anti-nuclear Ab AVA
90% have no C1q
poor clearance of apoptotic bodies

Systemic Lupus Erythematosus
SLE

29

outcome of SLE

protein deposits in the kidney, causing failure