Ch. 15 - Viral Infections of Skin Flashcards Preview

Microbiology > Ch. 15 - Viral Infections of Skin > Flashcards

Flashcards in Ch. 15 - Viral Infections of Skin Deck (16):
1

HSV 1 - Herpes Simplex Labia

Cold sores, fever blisters

Contagious

Primary infection - lips

Latent - trigeminal nerve (sensory ganglia)

Recurrence - move back to epithelium--> stressful triggers

2

Herpes Keratitis

HSV 1 in eye

Cause scarring of cornea --> blindness

Immunocompromised (HIV+) prone

3

HSV 2 - Herpes Simplex Genital

Genital herpes

Itching, blisters in genital area

No cure - antiviral ACYCLOVIR - to shorten and decrease # outbreaks

Acyclovir - base analog of DNA --> chain terminator

4

Neonatal herpes

From mom with HSV 2

Mental development delayed

Blindness, seizures

C section required

5

Varicella (VZV)

Chickenpox

Highly communicable - transmission via respiratory droplets or skin contact

Rash into infectious virus laden fluid

Spots at different stages of development (unlike smallpox)

Dormant in dorsal root ganglia-->reappear as shingles

Vaccine (1995): Varivax - attenuated virus

6

Zoster (VZV)

Shingles

Travel from dorsal root ganglia to body trunk -- one side only

Blisters

Can reoccur repeatedly

Facial paralysis, pain

Postherpetic neuralgia - shingles pain years after blisters have disappeared

Vaccine - Zostavax - attenuated

7

Roseola - HHV6

Infants

High fever, rash

Transmission via contact with respiratory secretions or saliva

8

Epstein Barr (EBV)

Oncogenes - Burkitt's lymphoma (nasopharyngeal cancer)

Infectious mononucleosis

9

Kaposi's Sarcoma (HHV 8 )

Oncogenes - tumor of blood vessel walls

Immunocompromised - AIDS --> opportunistic disease

Dark, purple lesions

10

Herpes viruses - general

Viral disease of the skin

Primary, latent, recurrent

Infect several types of epithelial cells and neural tissue --> cause a variety of skin and related issues

1. Herpes Simplex (HSV 1, HSV 2)
2. Varicella, Zoster (VZV)
3. Roseola (HHV6)
4. Epstein-Barr (EBV)
5. Kaposi's Sarcoma (HHV8)

11

Human Papilloma Virus (HPV)

Common warts (HPV 1 - HPV 4)
-benign skin growths
-plantar warts
-transmitted via contact or contaminate object

Genital Warts (Condylomata)
-HPV 6, HPV 11
-transmitted via sexual contact
-bumpy appearance
-no cure
-transmitted to newborns during delivery

Cervical Cancer
-HPV 16, HPV 18

12

Gardasil

Quadrivalent:
HPV 6, HPV 11 - Genital warts
HPV 16, HPV 18 - Cervical cancer

Men/Women: 9-26 years


13

Measles (Rubeola)

Contagious

Transmission via respiratory droplets

Koplik spots along gum line, near molars

Characteristic red rash - begin at hairline, spread to face/trunk/extremeties

14

Mumps (infectious parotitis)

Enlarged jaw - swollen salivary glands; blockage of ducts from parotid gland

Males: orchids (swelling of testes)

Transmission via respiratory droplets, contact with contaminated objects

15

Rubella (German Measles)

Acute, mildly infections

Transmission via respiratory droplets

Symptoms: fever, pink rash --> face to trunk spread

Recover, possible relapse

Congenital Rubella - most dangerous first trimester
-eye, ear, heart problems
-Gene Tierney --> deaf daughter

16

Smallpox (variola)

Contagious
Pink macules --> fluid-filled vesicles

Vesicles --> pustules-->break open, emit pus --> leave pitted scars (pocks)

No more vaccination after 1972 --> WHO smallpox dead 1980

Bioterrorism agent--> dangerous, no one immunized post 1972