Ch 18 Cancer Genes Flashcards Preview

2.2Elizi ex 2 GI 2 Exam 2 COPY > Ch 18 Cancer Genes > Flashcards

Flashcards in Ch 18 Cancer Genes Deck (12)
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1

ANA, ASMA, anti-LKM1, ACL-1

autoimmune hepatitis

2

ALDH1

alcoholic hepatitis

3

HFE (adult)
HAM, HJV (juvenile)

hemochromatosis

4

ATP7B

Wilson disease

5

a1AT

alpha1-AT def

6

HLA-B8 association, T cells in periductal stroma

PSC

7

polycistin gene (occurs with AR polycystic kidney dz)

fibropolycystic disease

8

HNF1 inactivation (germline mutaiton of MODY-3)
b-catenin activation
gp130 activation (IL6, JAK-STAT)

hepatocellular adenomas (benign)

9

APC, activation of WNT

hepatoblastoma

10

activation of b-catenin
inactivation of TP53 (aflatoxin)

hepatocellular carcinoma (malignant)

11

ABCG8

cholelithiasis

12

ERBB2 overexpression
PBRM1 mutation
MLL3 mutation

gallbladder carcinoma