Ch. 22: Microbial Diseases Of The Nervous System Flashcards Preview

Microbiology > Ch. 22: Microbial Diseases Of The Nervous System > Flashcards

Flashcards in Ch. 22: Microbial Diseases Of The Nervous System Deck (29):
1

What is meningitis?
Where is it found?

Inflammation of the meninges, the bacteria is found in the subarachnoid space within the cerebral spinal fluid

2

Can meningitis be life-threatening?

Depends on the kind

3

What are the meninges?

Collective covering over the brain and spinal cord, three layers (Dura, Arachnoid, Pia Mater) and there is the subarachnoid space which contains cerebral spinal fluids

4

How do you diagnose meningitis?

Spinal tap, if the fluid is cloudy it's an emergency

5

How would a person present if they had meningitis?

Sudden onset of fever, stiff neck, headache, and delirium

6

What are the three most common pathogens bacterial meningitis?

1) Streptococcus pneumoniae
2) Haemophilis Influenza
3) Neisseria Meningitis

7

What type of microbes can cause meningitis?

* Bacterial
* Viral
* Fungal
* Protozoans
* Anything except algae can find its way into the meninges

8

Tetanus produces a toxin called?

Tetanospasmin

9

C. tentani is a common ______ borne type a pathogen, and a very common _____ type of infection.

* Soil (Contaminated with animal feces)
* War

10

What pathogen causes botulism?

Clostridium botulinum

11

Botulism produces a variety of toxins and what's the most common one and what does it cause?

* Botulism Toxin A
* Causes flaccid paralysis, your muscles relax, there paralyzed in a relaxed state they can't contract and can be life-threatening

12

Botulism is a _____ borne type of pathogen

Food

13

Rabies is caused by what pathogen?

Lyssa virus

14

Rabies

* Virus
* Type of fatal encephalitis
* 100% mortality rate

15

Once the rabies virus has entered the neuron can the immune system stop it, why or why not?

No, because the immune system can't get inside the neurons where the virus is

16

In the US what's the number one reservoir for rabies?

Bats

17

What happens if you get bit by a rabid animal?

* Have to do a PEP (Post Exposure Prophylaxes)
* They gave you the immunoglobulin first and then the vaccine

18

What kind of animals are you more likely to get rabies from in the US?

* Bats
* Raccoons
* Skunks
* Foxes

19

What is the migration rate of the rabies virus?

15-100 mL/day

20

What pathogen causes TSE?

Prions

21

Where do you occasionally here about N. meningitis?

Outbreaks on college campuses, normally found in the upper respiratory tract, and mouth to mouth contact between students can spread it.

22

Tetanospasmin locks the muscles into a state called?

Tetany, muscles are locked into a fully contracted state

23

If someone presents with signs and symptoms of tetanus what might be the first thing you want to introduce them to?

* Tetanus Immunoglobulin (TIG)
* You wouldn't want to inject a vaccine because the immune system is failing and it takes 10 days to bump up your anti-body titer, and the person could be dead by then

24

What's the immunoglobulin for in tetanus?

Anti-Tetanospasmin antibodies, The anti-bodies go and attack and neutralize the toxin, which is the first thing you'd do

25

How do you designate a prion?

PrP^SC

26

What are some of the diseases caused by Prions?

* Mad cow disease
* Scrapie, affect sheep
* vCJD, human version of mad cow

27

How do you get Kuru?

Cannibalizing those who already have the disease

28

Which disease acquired from prions may be inherited and you don't start to presents with it until your mid 20s, and die from it a few years later?

vCJD and FFI (Fatal Familial Insomnia)

29

What happens when you have FFI?

You can't sleep and end up dying, there's no treatment