CH-22 PCN RxPREP MUST KNOWS

Question 1

Natural Penecillins

Answer 1

Penecillin G

Cover:
Gram positive cocci

• Strep pneumo
• Strep pyogenes
• Enterococcus

Gram positive anaerobes

• Peptostrepto
• propionibacterium
• Clostridium

Question 2

Aminopenecillins

Answer 2

Amoxicillin, Ampicillin

Gram positive Cocci

• Strep pneumo
• Strep pyogenes
• Enterococcus

Gram positive anaerobes

• peptostrepto
• propionibacterium
• clostridium

_Gram negative (HN*PEK) Rods_

Haemophilus, Neisseria*, Proteus,
E coli. Klebsiella

*Neisseria (cocci)

Question 3

Aminopenecillin + betalactamase inhibitor

Answer 3

Amoxicillin/clavulanate, ampicillin/subactam

Gram pos cocci

strep pneumo, strep pyogenes, enterococcus

Gram pos anaerobes

peptostrepto, propionibacterium, clostridium

Gram neg (HNPEK)

Haemophilus, Neisseria, Proteus,
E coli. Klebsiella

Gram neg anaeronbes

B-frag

Question 4

Extended Spectrum + betalactamase inhibitor

Answer 4

Pipercillin tazobactam

Adds CAPES

• Citrobacter
• Acinitobacter
• Provedencia
• Enterobacter
• Serratia

*Adds Pseudomonas****

Question 5

Antistaphylococcal PCN

Answer 5

Nafcillin, oxacillin

Cover MSSA and Streptococci ONLY

Question 6

Penecillin Class effects

Answer 6

They do NOT cover:

MRSA

Atypicals

• Chlamydia
• Legionella
• Mycoplasma pneumo
• Mycobacterium tuberculosis

Question 7

Natural penecillin formulations

Answer 7

PO: Pen VK

IV: Pen G Aqueous

IM Pen G Benzathine (Bicillin L-A)

Question 8

Antistaphyloccal PCN formulations

Answer 8

PO: Dicloxacillin

IV: Nafcillin, Oxacillin

Question 9

Outpatient PCN use

Answer 9

Pen VK:

• Strep throat, mild skin infx

Amoxicillin

• AOM
• Infective endocarditis (prophylaxis)
• H. Pylori

Amox/Clav

• AOM (lowest clav dose)

Question 10

Inpatient PCN use

Answer 10

Pipercillin/Tazo

• ONLY PCN active against PSEUDOMONAS

Nafcillin, Oxacillin, dicloxacillin

• MSSA & Streptococcus