Ch. 33 - Antivirals, Antimalarials, Anthelmintics Flashcards Preview

Pharm > Ch. 33 - Antivirals, Antimalarials, Anthelmintics > Flashcards

Flashcards in Ch. 33 - Antivirals, Antimalarials, Anthelmintics Deck (30)
Loading flashcards...
1
Q

Viruses:

A
  • More difficult to tx

- Reproduce by using host cell components

2
Q

Viral Infections:

A

Acute = (flu/cold)

Chronic = (herpes/HIV/MS/Alzeihemers)

3
Q

Influenza (1)

A

Highly contagious –>
-Affects: Resp system

Transmitted = contaminated droplets

3 main types of influenza = A,B,C

4
Q

Influenza (2)

A

Flu vaccine:

-Develop high antibody titer levels

5
Q

Herpesviruses :

A

HSV – 1 (COLD SORE)
HSV – 2 (genital herpes)
HSV – 3 (chicken pox/shingles)
HSV – 4 (Epstein-Barr)

Cytomegalovirus – affects salivary glands (preg woman stay away)

6
Q

Viral Infections:

A
  1. ) Hepatitis B (HBV)
  2. ) Human Immunodeficiency Virus (HIV)

Vaccines

7
Q

Antiviral Drugs (non-HIV):

A
  • Prevent or delay spread of viral infection

- Inhibit viral replication

8
Q

amantadine (Symmetrel):

A

Tx: Parkinsonism:
-Influenza A

Po = prophylactic use

9
Q

acyclovir (Zovirax) (1):

A
  1. ) Effective antiviral agent against:
    - Herpes simplex (2)
    - Herpes zoster (3)
    - Herpes encephalitis (3)
10
Q

acyclovir (Zovirax) (2):

A
  1. ) Po, IV, topical
  2. ) Short half-life (admin more freq)
  3. ) Interferes w/ viral synthesis of DNA

5.) Decrease healing time of active lesions

11
Q

acyclovir (Zovirax) (3):

A

Side Effects:

  • GI distress
  • HA, dizziness
  • Rash, urticaria
12
Q

acyclovir (Zovirax):

A

Adverse Reactions:

  • Gingival hyperplasia (overgrowth of gums)
  • Nephrotoxicity
13
Q

Teach: acyclovir

A
  1. ) Maintain adequate fluid intake
  2. ) Encourage good oral hygiene
  3. ) Report adverse reactions
14
Q

Neuraminidase inhibitors:

A

Decrease release of virus from infected cells =  -Decrease spread of virus
-Decrease duration of flu symp

15
Q

zanamivir (Relenza) / oseltamivir (Tamiflu):

A
  1. ) Take within 48 hr of flu symptoms
  2. ) Type A & B flu viruses
  3. ) Not the same as a ‘flu shot’
16
Q

Malaria (1):

A
  1. ) Protozoal organism
  2. ) Transmission
    • Carried by mosquitoes
    • Person – to – person contact
17
Q

Malaria (2):

A
  1. ) Transmission:
    * Ingest contaminated food or water
    * Contaminated syringe/needle
    * Direct contact w/ parasite
18
Q

Malaria (3):

A
  1. ) Parasites multiply in liver = infect red blood cells

5. ) Life-threatening = disrupting blood supply to vital organs

19
Q

Chloroquine HCl (tx: malaria):

A
  • Po, IM
  • Preventative measures:
    • Before the trip
    • While in the area
    • After return from the area
20
Q

Chloroquine HCl - Side Effects / Adverse Reactions:

A
  1. ) GI upset
  2. ) Blurred vision
  3. ) Hypotension
  4. ) Ototoxicity (hearing prob/loss)
21
Q

Chloroquine HCl - Nursing Interventions:

A

Monitor:

-Renal (kidney) & liver function

22
Q

Teach: chloroquine HCl

A
  1. ) Take po drug w/ food if GI upset occurs
  2. ) Report vision changes immediately
  3. ) Avoid consuming large amts alcohol
23
Q

Anthelmintics (Antihelminthics):

A

Helminths:

  • Parasitic worms
  • Most common form of parasitic disease

Most common site:
-Intestine

24
Q

Transmission:

A
  • Direct skin contact

- Ingesting food & water infested w/ worms

25
Q

Anthelmintics (Antihelminthics) cont…

A

Action:

  • Root out parasitic worms from the body:
    • Killing
    • Stunning
26
Q

Side Effects - Adverse Reactions:

A
  1. ) GI distress
    • Anorexia, n/v
  2. ) Neurologic SE
    • Dizziness, weakness, HA, drowsiness
27
Q

Nursing Interventions: antihelminthics

A
  1. ) Collect stools in a clean container

2. ) Adm meds with or immediately after meals

28
Q

Teaching (1): antihelminthics

A
  1. ) Handwashing!
  2. ) Daily showers = not baths
  3. ) Change sheets, bedclothes, towels & underwear daily
29
Q

Teaching (2): antihelminthics

A
  1. ) Don’t walk barefoot in infested area
  2. ) Wash vegetables & fruits before eating or cooking
  3. ) Proper cooking of beef & pork
30
Q

Teaching (3): antihelminthics

A

7.) Drowsiness may occur

  1. ) Compliance:
    • Drug tx, follow up

9.) Report SE/adverse reactions to health care provider