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Flashcards in Ch 7 Deck (50):
1

somatically generated epitope-specific t cell and b cell receptors

antigen specific receptors

2

t cells develop where

thymus

3

b cells develop where

bone marrow

4

develop initially in the bone marrow, but then migrate to the thymus to achieve full maturity

t cells

5

CD3 is derived from what

thymus

6

helper t cells
2/3 of mature CD3+ t cells
recognize nonpeptide-binding portion of MHC class II molecules (restricted)

CD4+ t cell

7

cytotoxic t cells
1/3 mature CD3+ t cells
recognize the nonpeptide-binding portion of MHC Class I molecules (restricted)
suppressor T cells

CD8+ t cell

8

downregulate adaptive responses

suppressor t cells

9

intracellular pathogens

cytotoxic t cells

10

extracellular pathogens

helper t cells

11

develop in the niche of the bone marrow

b cells

12

synthesis immunoglobulins and display on cell surface

b cells

13

arise from pluripotent stem cells
do not migrate to the thymus

b cells

14

self renewing that dominates plural and peritoneal cavities

b 1 cells

15

arise during and after neonatal period
continuously replaced from bone marrow
widely distributed throughout lymphoid organs and tissues
conventional b cells

b2 cells

16

derived from terminally differentiated b cells
immunoglobulin-producing
immunoglobulin-secreting
don't use Ig as membrane receptor
secrete Ig to fluids around cells
larger in size

plasma cells

17

lack TCR and BCR receptors
5-10% of peripheral blood cells
kill certain virally infected cells
kill certain tumor cells
granular appearance
bear KAR and KIR

natural killer cells

18

respond to lipids, glycolipids, or hydrophobic peptides presented by non-classical MHC I

NKT cells

19

where lymphocytes develop

primary

20

areas where immunogens contact lymphocytes

secondary

21

what are primary

thymus
bone marrow

22

what are secondary

spleen
lymph nodes
MALT

23

primary and secondary are connected to each other via what

blood and lymphatic circulatory system

24

regulate t can b cell development

stromal cells

25

cortical thymocytes do what

migrate to thymus

26

prothymocytes are what

stem cells originate in bone marrow

27

recognition of MHC I or II

positive selection

28

too strong of interaction with MHC killed by apoptosis

negative selection

29

eliminates thymocytes that react against self epitopes

negative selection

30

promotes thymocytes with receptors that interact with self MHC molecules. Eliminates those that cannot

positive selection

31

ensures that the immune system avoids destroying host tissue

tolerance

32

helps keep these anti-self recognition molecules/cells from circulating in the bloodstream

tolerance

33

remain in bone marrow for maturation
display IgM on surfaces
express auxiliary molecules
develop BCRs by DNA rearrangement

B cells

34

richly supplied with blood and lymphatic vessels
filtration system
areas where antigen encounters B or t cells

secondary

35

largest lymphoid organ
clears particulate matter from blood
concentrates blood-borne antigens and microbes
contains large numbers of B and t cells and plasma cells

spleen

36

white pulp of spleen

lymphocyte rich

37

red pulp of spleen

erythrocyte rich

38

leukocyte accumulations
function as filters for lymph
divided into cortex and medulla

lymph nodes

39

deep cortex is known as what and rich in what

paracortex
t cell rich

40

collection of lymphocytes and macrophages

medulla

41

thymus-independent area
germinal center-highly prolific

superficial cortex

42

important layer of defense against infection at mucosal and epithelial layers
organizes responses to antigens that enter mucosal tissues
includes a network of follicles and lymphoid microenvironments associated with the intestines

MALT
mucosa associated lymphoid tissues

43

what is associated with GALT

tonsils
peyers patches
intestinal villi

44

circulation of blood

cardiovascular

45

collects lymph

lymphatic

46

what are the two circulatory systems

cardiovascular and lymphatic

47

originate in connective tissues throughout body
collect plasma that continually leaks
forms extracellular fluid

lymphatic vessels

48

meeting places where lymphocytes coming from blood encounter pathogens and their products brought from infected connective tissue

lymph node

49

has no connections to the lymphatic system

spleen

50

use blood to enter and exit

lymphocytes