Ch 8- Depressive Disorders Flashcards Preview

Pharm ATI > Ch 8- Depressive Disorders > Flashcards

Flashcards in Ch 8- Depressive Disorders Deck (19):
1

SSRIs

Fluoxetine (Prozac)

Citalopram (Celexa)
Escitalopram (Lexapro)
Paroxetine (Paxil)
Sertraline (Zoloft)
Vilazodone (Viibryd)

2

SSRIs adverse effects

Sexual dysfunction

CNS stimulation (inability to sleep, agitation, anxiety)

Weight loss early in therapy

Serotonin syndrome (2-72 hrs)

Hyponatremia

Sleepiness, faintness, lightheadedness

GI Bleeding

Bruxism

3

Serotonin syndrome

Mental confusion
Fever
Agitation
Anxiety
Hallucinations
Incoordination
Diaphoresis
Tremors

4

SSRIs withdrawal syndrome

Headache
Nausea
Visual disturbances
Anxiety
Dizziness
Tremors

5

SSRIs interactions

MAOIs, TCAs, St. John’s worst increase serotonin syndrome

Fluoxetine increase warfarin levels

Fluoxetine increase levels of tricyclics antidepressants and lithium

Increased bleeding with NSAIDs

6

Atypical antidepressants

Bupropion HCL (Wellbutrin)

7

Atypical antidepressants adverse effects

Headache
Dry mouth
GI distress
Consitipation
Tachycardia
Nausea
Restlessness
Insomnia

Suppress appetite -weight loss

Seizures

8

Atypical antidepressants interactions

Phenelzine with MAOIs increase toxicity

9

Tricyclic antidepressants (TCAs)

-ine

10

TCAs adverse effects

Orthostatic hypotension

Anticholinergic effects

Sedation

Seizure

Excessive swearing

11

Anticholinergics effects

Dry mouth
Blurred vision
Photophobia
Urinary retention
Constipation
Tachycardia

12

Monoamine reuptake inhibitors (MAOIs)

Phenelzine (Nardil)

Isocarboxid (Marplan)
Tranylcyromine (Parnate)
Selegiline (Emsam) transdermal

13

MAOIs adverse effects

CNS stim (anxiety, agitation, mania)

Orthostatic hypo

Hypertension

14

Nursing admin therapeutic effects

1-3 weeks

15

Nursing admin full therapeutic effects

2-3 mo

16

SSRIs admin

am

With food

Older adults: sodium levels if on diuretics

17

Seasonal use of atypical antidepressants

Begin in autumn and taper dose and discontinue by spring

18

MAOIs foods to avoid

Tyramine (hypertensive crisis)

Yeast

Ex. Banana bread

19

Tyramine foods

Aged cheeses
Smoked or preserved fish or meats
Avocado
Figs
Bananas
Protein dietary supps
Soups with meat extracts
Soy sauce
Some beers
Red wine