Ch4 Cell Kill and Survival

Question 1

Tumor growth occurs when

Answer 1

not all neoplastic stem cells are killed

Question 2

Survival curves
- Raltionship between
- What is random?
- ___ function of dose

Answer 2

• Rad dose and amount of cells that survive
• Location of deposited energy
• Exponential

Question 3

Cells are killed by ___

Answer 3

Chance

Question 4

What is “saturation”

Answer 4

Accumulation of damage per each cell

Question 5

Cell kill
- Is not a ___ phenomena
- Reffered to as

Answer 5

• 1 to 1
• Exponential

Question 6

Cell survival curve is a ___ graph

Answer 6

Semi-logarithmic

Question 7

On a cell survival cuve
- x-axis stands for
- y-axis stands for

Answer 7

• Dose
• Surviving fraction of cells plotted

Question 8

A cell survival curve is showing the

Answer 8

relation of survival/death and dose used to kill

Question 9

Depicted by a shoulder followed by a curve that identifies at
what does there is zero cell survival

Answer 9

Indicates cell sensitivity!!

Question 10

Target theory (killing mechanism)
- states that

Answer 10

There are “N” targets in a cell which must be hit to kill it. But If one target is missed the cell will survive.

Question 11

Target theory
- N stands for
- N-1 stands for

Answer 11

• number of targets or DNA in a cell needed to be hit in order to produce cell kill
• Population has only one target in each cell that must be hit to be killed (All but one target have been killed, “Threshold dose”

Question 12

N number in humans range from

Answer 12

2-10

Question 13

Dq or quasi stands for ___ dose

Answer 13

Threshold dose

Question 14

Do stands for ___ dose

Answer 14

Terminal slope dose

Question 15

Do
- The dose that kill ___% of population
- Represents

Answer 15

• 37%
• Cell survival

Question 16

Do
- Shallow curve represents
- Steep curve represents

Answer 16

• Radioresistant
• Radiosensitive

Question 17

Dq
- defines on a graph
- represents

Answer 17

• Width of the shoulder region
• cells ability to accumulate and reapir sublethal damage

Question 18

Do in mammalian cells is ___

Answer 18

1-2 Gy

Question 19

Sublethal damage (SLD) occurs when

Answer 19

two doses are seperated by time

Question 20

SLD
- One more dose is given to DNA
- No more doses are given DNA

Answer 20

• It Dies
• Is Repaired

Question 21

Sublethal damage relates with a cells

Answer 21

Ability to repair

Question 22

SLD fractionation promotes

Answer 22

repair

Question 23

If full dose is delivered at once what would not be possible

Answer 23

Repair

Question 24

Potentially Lethal Damage (PLD) occurs when

Answer 24

post irradiated conditions are modified

Question 25

Cell death most likely to occur in which condition

Answer 25

optimal nutritional conditions, because the cell can divide

Question 26

Cell death is less likely in sub optimal conditions because

Answer 26

Cells are in hibernation and have to repair the damage and wont divide

Question 27

cell death is seen as the

Answer 27

decrease in the number of cells that can reproduce