Ch4: Skin, Musculoskeletal, Blood, and Lymph Part II Flashcards Preview

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Flashcards in Ch4: Skin, Musculoskeletal, Blood, and Lymph Part II Deck (289)
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1

Infections of joint and bone include? 4

1. Parovirus B19: Developed countries (Slapped cheek)
2. Rubella: Nonvaccinated adults
3. Hep B: HIV-1 and HTLV-1
4. Alphavirus

2

5 classic childhood viral rashes?

1. Measles: Rubeola
2. German measles: Rubella
3. Roseola
4. Fifth disease
5. Chickenpox: Varicella zoster

3

5 herpes virus of skin?

1. Herpes simplexes 1 and 2
2. Varicella zoster
3. Human herpes virus 6, 7, 8
4. EBV
5. CMV

4

4 families of viruses of skin?

1. Herpes
2. HPV
3. Coxsackie
4. Poxviruses

5

3 subfamilies of herpesvirus?
Which has short growth cycle?
Which has long?

Alpha: Short
Beta: Long
Gamma

6

Members of alpha herpes family? 3

HSV-1
HSV-2
Varcicella Zoster

7

Members of gamma herpes family? 2

EBV: HSV-4
Kaposi' sarcoma: HHV-8

8

Members of beta herpes family? 3

CMV (HHV-5)
HHV-6
HHV-7

9

In terms of herpes
Size?
Envelope presence?
Genome shape?
Genome type?
Shape of capsule?

Large
Enveloped
Linear
DsDNA
Icosadeltahedral

10

Since herpes have a capsule, they have a tegument which contains what?

Enzymes for replication

11

What determines what cell/tissue, the herpes virus attacks?

Receptors

12

What are the viral adhesins of herpesvirus?

Envelope glycoproteins

13

What is the primary manifestation of herpesvirus in humans?

Common infections but benign in children

14

What is the immune response of herpesvirus?

CMI

15

What is the primary treatment of herpesvirus?

Targeting viral DNA polymerase

16

What main feature do all herpesviruses have?

Latency

17

How do viruses do latency? (2)

1. Make non-encoding transcripts that prevent apoptosis
2. Express proteins during latency

18

What is state of herpesvirus genomes during latency?

Circular, episomal form separate from host genome

19

How are herpesviruses spread? 3

Respiratory droplets
Oral mucosa
DIrect contact

20

What herpesviruses can be be spread without symptoms?

HSV 1-2
EBV 4
CMV 5
HHV-6
HHV-7

21

When is VZV transmitted?

Only when patient has varicella or zoster

22

What is required for HSV spreading?

Direct contact

23

Most herpesviruses are diagnosed how?

Clinical symptoms

24

What is used in confirming acute or previous herpesvirus infection?

Serology

25

PCR is used to test what herpesvirus?

1-6

HSV 1-2
VZV 3
EBV 4
CMV 5
HHV-6

26

How to detect VZV in ski nlesions?

Ab testing

27

What herpesviruses cause both intranuclear and cytoplasmic inclusions?

CMV 5
HHV-6

28

What herpesviruses result in only intranuclear inclusions?

HSV 1-2
VZV 3

29

HSV 1-2 infection
Can infect what cell types?
Where is it lytic? (2)
Where is it latent?

Most cell types
Mucoepithelial and fibroblasts
Neurons

30

Where does HSV-1,2
initially attach?
What gives it a tight binding? (2)
What does gC do?
What does gE and GI do?

Heparin sulfate proteoglycans

Nectin-1alpha and HVEM

Binds to and depletes C3 from seru

Complex with Fc on IgG