Flashcards in Ch5: URT Chaussee Deck (104)
What does upper respiratory mean?
How does number of microbes change throughout lung?
Very high in the mouth
Decreases as you move down the respiratory tract
None in lungs
Where does RT become aseptic?
Normal flora has what role in RT?
Protects by competing with harmful microbes
What bacteria are in middle ear and sinuses?
Normal flora of URT? (50% of people or more)
2. Candida albicans
3. Alpha-hemolytic strep
4. Strep mutants
5. Haemophilus influenzae
7. Non staph aureus staph
Host defenses in URT?
1. Orthogonal structure
3. Mucin and mucus
the orthagonal structure of URT has what effect?
What does saliva contain? 2
What does mucus do?
Traps microbes from entering LRT.
What sweeps mucus up and out and into stomach?
Ciliated epithelial cells
Ciliated epithelial cells + Mucus = ?
50-70% of sore throats are caused by what in children?
What symptoms suggest a viral sore throat?
What percentage of adult sore throats are viral?
Bacterial causes of pharyngitis?
1. Group A strep:
2. Group C and G strep
3. Anaerobes (bacterioides, fusobacterium, spirochetes
4. Corynebacterium diptherae
5. Neisseria gonorrhoea
Which bacterial causes of pharyngitis are common?
Group A strep = common
Group C and G strep = infrequent
Neisseria gonorrhea = infrequent
GAS caused pharyngitis has what associations? 3
Tonsilitis, scarlet fever, sequelae
What are spirochetes that cause pharyngitis?
What else are they associated with?
Borrelia and treponema
In terms of GAS strep throat
1. Severe pain
2. Difficulting swallowing
Suppurative sequelae of GAS? 4
1. Peritonsillar abscess
2. Otitis media, sinusitis, mastoiditis
3. Scarlet fever
4. Streptococcal Toxic Shock Syndrome
Scarlet fever encompasses what?
Peripheral rash (Maybe strawberry tongue) caused by SPE's
What is STSS due to?
Production of Spe's that act as superantigens
What happens if GAS is in the blood?
Bacteremia and toxigenic disease
Non-suppurative/post infection sequelae to GAS pharyngitis?
Acute rheumatic fever: Due to autoimmune
Why does acute rheumatic fever occur?
How long does it take to develop?
What percent of kids get it?
M protein mimics cardiac myosin
Clinical diagnosis of ARF is based on what?
ARF typically follows what type of GAS infection?
What is the Jones criteria requirements for GAS?
Evidence of previous GAS infection
2 major or 1 major + 2 minor