Chapter 1 - Introduction Flashcards Preview

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Flashcards in Chapter 1 - Introduction Deck (11):
1

Average cost of drug discovery process?

$100-2000m

2

Aspects of drug discovery project

Operational
Strategic
Scientific and technical

3

Components of strategic aspect of discovery process

1. Unmet medical need
2. Market predictions
3. Company strategy and franchise
4. Company pipeline
5. Legislation, government policy, reimbursement, pricing

4

Most common causes of death in low-income countries

Infectious:
Respiratory infections
HIV/AIDS
Diarrhoeal diseases

5

Most common causes of death in high-income countries

Chronic diseases:
Ischaemic heart disease
Stroke
Lung cancer
Alzheimer's

6

Most common global causes of death

Ischaemic heart disease
Stroke
COPD
Respiratory infections
Lung cancer

7

Most prevalent diseases globally

Dental caries,
Head-ache,
Migraine,
-
-
Acne vulgaris,
-
Back ache

8

What is the perfect drug?

A free drug
Given once orally
With no side effects
Cures the condition

9

Components of operational aspect of discovery process

1. Staff
2. Facilities
3. Costs
4. Timescale

10

Components of scientific and technical aspect of discovery process

1. Strength of hypothesis
2. Availability of targets and "drug ability"
3. Availability of assays
4. Animal models
5. Chemical starting point
6. Patent situation and freedom to operate
7. Competition
8. Formulation & route of administration
9. Toxicology
10. Chemical development
11. Regulatory hurdles
12. Production

11

Give 5 therapeutic modalities

Small molecular entity
Biologics
Gene therapy
Cell based therapy
Organ and tissue transplant