Chapter 10 Flashcards Preview

Immunology > Chapter 10 > Flashcards

Flashcards in Chapter 10 Deck (30):
1


B lymphocytes are made in the:

bone marrow.

2

How long does B cell maturation from an HSC to a mature B cell take?

1 to 2 weeks

3

Which cell type is found in both B- and T-cell lineages?


Common lymphoid progenitors

4

This type of cell will leave the bone marrow and complete maturation in the spleen.

immature B cell

5

All of the following are true regarding B-cell development EXCEPT:

B cells, like T cells, are MHC class restricted.

6

Hematopoiesis produces:

erythorid, lymphoid, and myeloid lineage cells.

7

Hematopoiesis begins at around day 7 after fertilization in mice. What is the site of precursor cells at this stage of fetal development?

Yolk sac

8

At what site can fetal HSCs be found by day 8 in the mouse model?

AGM (aorta-gonad-mesonephros)

9

At what site(s) can mature HSCs be found by day 11 in the mouse model?

All of the above

10

What type of cell will predominately be produced by hematopoiesis in the fetal liver of mice?

Erythroid lineage cells

11

VDJ recombination occurs during which phase of a B cell’s development?

Pro-B cell

12

What are two functions of bone marrow stromal cells with respect to B-cell development?

Cytokine expression and traps developing B cells in a specific location

13

Individuals of retirement age or older show lower antibody mediate immune responses due to all of the following reasons EXCEPT:

smaller thymus.

14

What type of immunoglobulin gene rearrangement occurs during B-cell progenitor development?

Both heavy- and light-chain rearrangement

15

The common lymphoid progenitor cell gives rise to all of the following cell lines EXCEPT:

megakaryocytes.

16

Which of the following statements regarding HSCs is/are TRUE?

Statements II and IV only

17

Where can early lymphoid progenitor cells (ELPs) be found in humans?

Bone marrow

18

At what stage of development does a B cell begin to express a pre-B-cell receptor?

Late pre-B cell

19

At what stage of development does a B cell undergo D-JH rearrangement?

Early pro-B cell

20

At what stage of development does a B cell begin to display an IgM receptor?

Immature B cell

21

B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful VH-DJH combination that does not recognize self. If no successful combination is produced, then the B cell will undergo apoptosis. At what point of B-cell development does this checkpoint occur?

Late pro B cell

22

How does allelic exclusion prevent multiple heavy-chain rearrangements from occurring in pre-B cells?

RAG1 and RAG2 are down-regulated, and TdT activity is lost so that no additional heavy-chain rearrangements may take place.

23


Mature naïve B cells express high levels of ____ on their cell surfaces.

IgD

24


Mature B-2 or follicular B cells are most commonly found in the:

secondary lymphoid organs.

25

Mature B-1 cells show ______ diversity in their V-region.

low (restricted)

26

Marginal-zone B cells express:

Both B and C

27

Which type of mature B cell is MOST likely to respond to a protein antigen?

B-2 B cells and MZ B cells

28

What is the initial location of B-cell and T-cell development?

Bone marrow for both B cell and T cell

29

Which cell type undergoes negative selection of ectopic expressing self-antigen cells in primary lymphoid organs?

T cells

30


V-J rearrangement occurs in:

both B cells and T cells.