Flashcards in Chapter 10 Deck (30):
B lymphocytes are made in the:
How long does B cell maturation from an HSC to a mature B cell take?
1 to 2 weeks
Which cell type is found in both B- and T-cell lineages?
Common lymphoid progenitors
This type of cell will leave the bone marrow and complete maturation in the spleen.
immature B cell
All of the following are true regarding B-cell development EXCEPT:
B cells, like T cells, are MHC class restricted.
erythorid, lymphoid, and myeloid lineage cells.
Hematopoiesis begins at around day 7 after fertilization in mice. What is the site of precursor cells at this stage of fetal development?
At what site can fetal HSCs be found by day 8 in the mouse model?
At what site(s) can mature HSCs be found by day 11 in the mouse model?
All of the above
What type of cell will predominately be produced by hematopoiesis in the fetal liver of mice?
Erythroid lineage cells
VDJ recombination occurs during which phase of a B cell’s development?
What are two functions of bone marrow stromal cells with respect to B-cell development?
Cytokine expression and traps developing B cells in a specific location
Individuals of retirement age or older show lower antibody mediate immune responses due to all of the following reasons EXCEPT:
What type of immunoglobulin gene rearrangement occurs during B-cell progenitor development?
Both heavy- and light-chain rearrangement
The common lymphoid progenitor cell gives rise to all of the following cell lines EXCEPT:
Which of the following statements regarding HSCs is/are TRUE?
Statements II and IV only
Where can early lymphoid progenitor cells (ELPs) be found in humans?
At what stage of development does a B cell begin to express a pre-B-cell receptor?
Late pre-B cell
At what stage of development does a B cell undergo D-JH rearrangement?
Early pro-B cell
At what stage of development does a B cell begin to display an IgM receptor?
Immature B cell
B-cell development has one checkpoint to determine if V-DJ rearrangement has produced a successful VH-DJH combination that does not recognize self. If no successful combination is produced, then the B cell will undergo apoptosis. At what point of B-cell development does this checkpoint occur?
Late pro B cell
How does allelic exclusion prevent multiple heavy-chain rearrangements from occurring in pre-B cells?
RAG1 and RAG2 are down-regulated, and TdT activity is lost so that no additional heavy-chain rearrangements may take place.
Mature naïve B cells express high levels of ____ on their cell surfaces.
Mature B-2 or follicular B cells are most commonly found in the:
secondary lymphoid organs.
Mature B-1 cells show ______ diversity in their V-region.
Marginal-zone B cells express:
Both B and C
Which type of mature B cell is MOST likely to respond to a protein antigen?
B-2 B cells and MZ B cells
What is the initial location of B-cell and T-cell development?
Bone marrow for both B cell and T cell
Which cell type undergoes negative selection of ectopic expressing self-antigen cells in primary lymphoid organs?