Chapter 16 lecture 3

Question 1

Who does graft versus host disease occur in?

Answer 1

-Recipients of allogeneic bone marrow transplantations

Question 2

If a person has chronic CVHD what percent have oral involvement?

Answer 2

-80%

Question 3

What do oral lesions of GVHD look like?

Answer 3

-Lichen planus

Question 4

What is used to treat focal oral ulcerations in GVHD?

Answer 4

Topical corticosteroids

Question 5

What is the most common collagen vascular or connective tissue disease in the US?

Answer 5

-Lupus Erythematous

Question 6

What are the common findings of SLE?

Answer 6

• Fever
• Weight loss
• Arthritis
• Fatigue
• Malar rash (butterfly rash)

Question 7

What can make the malar rash worse in SLE?

Answer 7

-Sunlight

Question 8

What is the most significant aspect of SLE?

Answer 8

-Kidney failure

Question 9

Up to 50% of SLE have warty vegetations affecting heart valves termed what?

Answer 9

Libman-Sacks endocarditis

Question 10

What is mild Lupus Erythematous managed by?

Answer 10

• NSAIDS

- Antimalarial (hydroxychloroquine)

Question 11

What is the first sign of systemic sclerosis?

Answer 11

-Raynauds Phenomenon

Question 12

What is a disease in which dense collagen is deposited in the tissues of the body in extraordinary amounts?

Answer 12

-Systemic sclerosis

Question 13

What is Raynauds Pehnomenon?

Answer 13

• Vasoconstrictive triggered by emotional distress or exposure to cold
• Not specific for systemic sclerosis

Question 14

Characteristic furrows radiating from the mouth produce a purse string appearance in what disease?

Answer 14

-Systemic sclerosis

Question 15

T/F Pts with systemic sclerosis have a 70% reduction in opening of the mouth

Answer 15

True

Question 16

What is a mild variant of systemic sclerosis known as?

Answer 16

-Localized scleroderma

Question 17

Localized scleroderma has lesions that look like scars termed what?

Answer 17

-En coup de sabre “strike of the sword”

Question 18

What is CREST syndrome?

Answer 18

• Calcinosis cutis
• Raynauds phenomenon
• Esophageal dysfunction
• Sclerodactyly
• Telangiectasia

Question 19

Benign acanthosis nigricans may be caused by what?

Answer 19

• Obesity
• Inheritance
• Various endocrinopathies
• Various syndromes
• Various drugs

Question 20

If you have benign acanthosis nigricans caused by obesity what is that termed?

Answer 20

-Pseudoacanthosis nigricans

Question 21

In acute GVHD the skin lesions range from a mild rash to diffuse and sever sloughing that resembles what?

Answer 21

-Toxic epidermal necrolysis

Question 22

What does chronic GVHD mimic?

Answer 22

• SLE

- Sjogrens syndrome

Question 23

What are the different types of Lupus erythematosus

Answer 23

• SLE
• Chronic cutaneous lupus erythematous
• Subacute cutaneous lupus erythematous

Question 24

What does acanthsis nigricans appear like?

Answer 24

• Velvety

- Brown

Question 25

Which lesions of acanthisis nigricans are benign?

Answer 25

-Cutaneous lesions