Chapter 29 - Analytical Toxicology Flashcards Preview

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Flashcards in Chapter 29 - Analytical Toxicology Deck (24):
0

The largest group of substances that must be considered by analytical toxicologists are...

A. Nonvolatile organic substances

B. metals

C. Gases

D. Volatile substances

A. Nonvolatile organic substances

1

If a human sample is made basic and extracted with an organic solvent and then the nonorganic phase is acidified and extracted again with organic solvent the final organic extract will contain mostly...

A. Basic drugs

B. Neutral drugs

C. Acidic drugs

D. Volatiles

C. Acidic drugs

2

Venoms usually need to be measured by a combination of monoclonal antibodies and...

A. Gas chromatography

B. infrared spectroscopy

C. Liquid chromatography

D. Immunoassay

D. Immunoassay

3

Analytical toxicology measurements are least valuable in...

A. Establishing bioavailability of a poorly absorbed drug

B. assessing pharmacodynamic drug interactions

C. Identifying contaminants in a drug mixture

D. Assessing pharmacokinetic drug interactions

B. assessing pharmacodynamic drug interactions

4

In order for an analytic toxicology result to be entered into legal proceedings, there usually must be...

A. Chain of custody

B. 3 repeat analyses

C. Blood results, not tissue or urine

D. Analysis by a board-certified forensic toxicologist

A. Chain of custody

5

The precision of an analytic toxicology result is related to...

A. Location value falls on standard curve

B. Accuracy of value on repeated measurements

C. Whether dilution was necessary

D. Accuracy of blood value compared to tissue

B. Accuracy of value on repeated measurements

6

Identification of anhydroecgonine methyl ester along with cocaine metabolites in the urine is an indication that...

A. Cocaine was adulterated with PCP

B. cocaine was administered orally

C. Cocaine was smoked

D. Cocaine was ingested with ethyl alcohol

C. Cocaine was smoked

7

The least useful specimen for quantitative toxicologic analysis is...

A. Blood

B. liver

C. Urine

D. Vitreous humor

C. Urine

8

By identifying the presence of certain impurities in biological samples obtained after consumption of an illicit substance one can...

A. More accurately predict the time of ingestion

B. More accurately predict the mode of ingestion

C. More accurately predict drug-drug interactions

D. Possibly identify the source of the illicit material

D. Possibly identify the source of the illicit material

9

The classic Mickey Finn of the nineteenth century was a mixture of ethyl alcohol and..

A. Isopropyl alcohol

B. Chloral hydrate

C. Butalbital

D. Meprobamate

B. Chloral hydrate

10

A child who is intentionally poisoned by parents to repeatedly appear ill is part of a syndrome known as...

A. Munchausen syndrome

B. Munchausen by proxy syndrome

C. Borderline personality syndrome

D. DSM IV syndrome

B. Munchausen by proxy syndrome

11

Analysis of how much hair will provide an approx monthly pattern of arsenic exposure?

A. 1 mm

B. 5 mm

C. 12 mm

D. 25 mm

C. 12 mm

12

All of the following tests can help detect adulteration of a urine specimen for forensic testing except...

A. pH

B. creatine

C. Specific gravitiy

D. Pressure of WBCs

D. Pressure of WBCs

13

In order to distinguish heroin use from poppy seed ingestion one should look for the presence of...

A. 6-monacetylmorphine

B. Morphine glucuronide

C. Codine

D. Hydromorphone

A. 6-monacetylmorphine

14

All of the following are commonly used to adulterate urine for drug testing purposes except...

A. Bleach

B. Baking soda

C. Glutaraldehyde

D. Methylene blue

D. Methylene blue

15

Use of Vicks inhaler may result in a false positive urinary drug screen for...

A. Opiates

B. PCP

C. D-methamphetamine

D. L-methamphetamine

C. D-methamphetamine

16

A rapid quantitative determination of serum conc of all of the following drugs is required in an overdose setting except

A. Acetominophen

B. ethanol

C. Ibuprofen

D. Ethylene glycol

C. Ibuprofen

17

A commonly used term to denote the serum level of a drug that should be immediately reported to the treating physician is...

A. Panic level

B. Lethal level

C. Toxic level

D. Subtherapeutic level

A. Panic level

18

Traditionally, therapeutic frug monitoring has been performed for all of the following drug classes except...

A. Antimicrobials

B. Antihypertensives

C. Anticonvulsants

D. Antiarrhythmins

B. Antihypertensives

19

In usual cases, toxicologic analysis of dead bodies has involved the use of all of the following except...

A. Maggots

B. Hair

C. Clothing

D. Bones

C. Clothing

20

Interference with toxicologic analysis will least likely result from contaminants present in...

A. Specimen containers

B. Air

C. Lids

D. Stoppers

B. Air

21

When analyzing a specimen where extraction efficiency is highly variable, one can use the method of...

A. Standard additions

B. Least squares

C. Standard curves

D. Internal standards

A. Standard additions

22

Which of the following would be thought to have the highest degree of post-mortem redistribution?

A. Mecuric ion

B. Ethanol

C. Paraquat

D. Imipramine

D. Imipramine

23

Which of the following is true of a urine drug screen?

A. Chain of custody is not required for forensic evidence

B. over 50 drug classes can be rapidly screened

C. There is a poor correlation between levels and clinical effects

D. They are commonly run by HPLC

C. There is a poor correlation between levels and clinical effects