Chapter 35 - Hypothalamic and Pituitary Agents Flashcards Preview

Nur 30 Pharmacology > Chapter 35 - Hypothalamic and Pituitary Agents > Flashcards

Flashcards in Chapter 35 - Hypothalamic and Pituitary Agents Deck (10):
1

Leuprolide Indications

Indications:

Treatment of...
1. Advanced Prostatic Cancer
2. Endometriosis
3. Central percocious puberty
4. Uterine Leiomyomata

2

Leuprolide Actions

GnRH agonists that occupies pituitary GnRH receptors and desensitizes them; causes an initial increase and then profound decrease in LH and FSH levels.

3

Leuprolide Adverse Effects

Agonists can lead to increased release of sex hormones leading to ovarian overstimulation

hot flashes
MI
urinary frequency
hematuria
People with peripheral vascular disorders

4

Somatropin Indications

Growth Hormone Agonist

Long term treatment of children with growth failure associated with various deficiencies.
Girls with Turner's syndrome, AIDS wasting and cachexia, GH deficiency in adults
Treatment of growth failure in children of small gestational age who do not achieve catch up growth by 2 years of age

5

Somatropin Actions:

Replaces human GH, stimulates skeletal growth, growth of internal organs, and protein synthesis

6

Somatropin Adverse Effects

Development of antibodies to growth hormone
insulin resistance
joint pain

7

Somatropin Contraindications

Closed epiphyses
underlying cranial lesions
abdominal surgery
complications of open heart surgery

8

Bromocriptine Indications

Growth Hormone Antagonist
Treatment of...
1. Treatment of Parkinson's disease
2. Hyperprolactemia associated with pituitary adenomas
3. Female infertility associated with hyperprolactemia
4. Acromegaly

9

Bromocriptine Actions

Acts directly on postsynaptic dopamine receptors in the brain

10

Bromocriptine AE & D-D

Postural hypotension
Blocks lactation

Dont use with erythromycin or phenothiazines.