Chapter 37 - Thyroid and Parathyroid Agents Flashcards Preview

Nur 30 Pharmacology > Chapter 37 - Thyroid and Parathyroid Agents > Flashcards

Flashcards in Chapter 37 - Thyroid and Parathyroid Agents Deck (20):
1

Levothyroxine (I)

Thyroid Hormone
Replacement therapy in hypothyroidism
Pituitary thyroid stimulating hormone suppression in the treatment of euthyroid goiters and in the management of thyroid cancer
Thyrotoxicosis in conjunction with other therapy
myxedma coma

2

Levothyroxine (A)

Increases the metabolic rate of body tissues
increasing oxygen consumption, respiration, and heart rate
the rate of fat, protein, and carb metabolism, and growth and maturation

3

Levothyroxine (AE)

Tremors
Loss of hair in first few months with children
difficulty swallowing
TAKE DRUG WITH FULL GLASS OF WATER

4

Levothyroxine (D-D & CI)

CI:
Acute MI
Thyrotoxicosis (unless used in conjunction with antithyroid drugs)
Addisons Disease

D-D:
Anticoagulants (^effect)
Digitalis Glycosides (v effect)
Theophylline

5

Methimazole (I &A)

Antithyroid Thiamide
Treatment of hyperthyroidism
Inhibits the synthesis of thyroid hormones

6

Methimazole (AE)

Bonemarrow suppression
Parethesias
skin pigmentation
epigastric distress (but less than others)

7

Methimazole (D-D & CI)

CI:
Pregnancy (baby develops cretinism
Feeding (baby can get a goiter)

D-D:
none

8

Strong Iodine Products (I&A)

Antithyroid Iodine Solutions
Indications:
Adjunct therapy for hyperthyroidism; thyroid blocking in a radiation emergency
Actions:
Inhibits the synthesis of thyroid hormones and inhibit the release of these hormones into the circulation.

9

Strong Iodine Products (AE)

hypothyroidism (PT will need replacement therapy)
goiter
iodism
swelling of salivary glands

10

Strong Iodine Products (CI&D-D)

CI:
Pulmonary edema or pulmonary TB

D-D:
Drugs that have a small margin of safety:
anticoags
theophylline
digoxin
metoprolol
propanolol

11

Calcitriol (I)

Antihypocalcemic Agent

Management of hypocalcemia in patients on chronic renal dialysis
Management of hypocalcemia ass. with hypoparathyroidism

12

Calcitriol (A)

A vitamin D compound that regulates the absorption of calcium and phosphate from the small intestine, mineral resorption of bone, and reabsorption of phosphate from the renal tubules, increasing the serum calcium levels.

13

Calcitriol (AE)

Weakness, dry mouth, bone pain, metallic taste

14

Calcitriol (CI & D-D)

Hypercalcemia or vit. D toxicity
History of renal stones

d-d:
hypermagnesemia if taken with magnesium containing antacids

Reduced absoprtion if taken with mineral oil because they're fat soluble vitamins.

15

Alendronate (I&A)

Antihypercalcemic Biphosphate
Treatment and prevention of osteoporosis in postmenopausal women and in men
Glucocorticoid induced osteoporosis
Paget's disease in certain patients

Slows normal and abnormal bone resorption without inhibiting bone formation and mineralization.

16

Alendronate (AE)

Long term use (+5 years) ass. with increased risk of femoral shaft fractures
Esophageal erosion
Bone pain

17

Alendronate (CI&D-D)

CI:
Needs to be taken in the morning 30 minutes before any food or beverage.Must remain upright for 30 minutes.
Hypocalcemia
Causes Fetal abnormalities

D-D:
Antacids/calcium products/iron/multivits (v effects)
GI distress if taken with aspirin

18

Calcitonin Salmon (I&A)

Antihypercalcemic Calcitonin
I: Paget's Disease, postmenopausal osteoporosis, emergency treatment of hypercalcemia
A: Inhibits bone resorption; lowers elevated serum calcium in children and patients with Paget's disease; increases the excretion of filtered phosphate, calcium, and sodium by the kidney

19

Calcitonin Salmon (AE)

Flushing of face and hands, urinary frequency

20

Calcitonin Salmon (CI&DD)

CI: Known allergy to salmon or fish products
Pernicious anemia

DD: None