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Flashcards in Chapter 4- Pharchem lec Deck (60):
1

Principal metabolic function of Iron

Constituent of hemoglobin

2

Principal metabolic function of Iodine

Constituent of thyroxine, triiodothyronine

3

Principal metabolic function of Cobalt

Constituent of Vit. B12 (cyanocobalamin)

4

Principal metabolic function of Zinc

Constituent of insulin and carbonic anhydrase

5

Principal metabolic function of Copper

Formation of hemoglobin increase iron utilization constituent of oxidase enzymes

6

Principal metabolic function of Sulfur

Constituent if proteins mucopolysaccharides, heparin, biotin, detoxication

7

Clinical manifestation of deficiency of Iron

Anemia

8

Clinical manifestation of deficiency of Iodine

Endemic (simple) goiter, cretenism

9

Clinical manifestation of deficiency of Cobalt

Deficiency of Vit. B12 - pernicious anemia
Excess - polycythemia

10

Clinical manifestation of deficiency of Zinc

Anemia, stunted growth, hypogonadium in male

11

Clinical manifestation of deficiency of Copper

Hypochromic anemia, excessive heptic storage in Wilson's disease

12

Clinical manifestation of deficiency of Sulfur

Cystinuria, cystine renal calculi

13

Essential to the elementary metabolic process in cell

Iron

14

Functions as an electron carrier in the respiration chain

Iron

15

Responsible for the transport of molecular oxygen in higher organisms

Iron

16

Two types of proteins commonly assiciated with iron

1. Hemoproteins
2. Iron-storage and/or transport proteins

17

Iron-containing proteins responsible fir respiration and for carrying oxygen

Hemoproteins

18

Example of a respiratory enzyme in which iron is complexed in phorohyrin ring bonded covalently with the protein portion of the molecule

Cytochrome C

19

Hemoproteins responsible for storing and/or transporting oxygen

Myoglobin and hemoglobin

20

Water doluble, crystallizable iron protein built up from apoferritin and micelles of a colloidal ferric hydroxide phosphate complex

Ferritin

21

Water insoluble and is considered as dehydrated ferritin

Hemosiderin

22

Found in the liver, spleen and bone marrow

Ferritin and hemosiderin

23

Major iron transport protein of blood plasma

Glycoprotein known as transferrin

24

Condition wher the curculating red blood cells are deficient in number or deficient in the total hemoglobin content per unit of blood volume

Anemia

25

Anemia can be caused by:

1. Excessive blood loss
2. Blood destruction
3. Decreased blood formation

26

Have specialized biochemichal functions although they are not found in the general electrolyte replacement preparations.

Essential ions

27

FeSO4•7H20

Ferrous Sulfate

28

Synonyms of Ferrous Sulfate

Iron sulfate, copperas, green vitriol, iron vitriol

29

Occurs as pale, bluish green crystals or granules which are odorless

Ferrous sulfate

30

Most widely used oral preparationand is the drug of choice for treating uncomplicated iton deficiency anemia

Hematinic

31

Essential ion necessary for the synthesis of the two hormones produced by the thyroid gland, trilodothyronine and thyroxine

Iodide

32

Daily iodine requirement for an average man

Approximately 140 micrograms

33

Daily iodine requirement for an average female

About 100 micrograms

34

Characterized by swelling at the neck

Colloid goiter

35

Iodide has been used therapeutically as:

1. Ameliorating agent in hyperthyroidism
2. Fibrolytic agent in syphilis, leprosy, etc.,
3. Expectorant
4. Alternative

36

Certain irritative phenomena to tge skin and mucous membranes exhibited by coryza, rashes, headache, laryngitis and the like

Iodism

37

Indispensable for normal metabolism and found in adequate amounts in food, water and cooking utensils

Copper

38

Three postulates on the roles of copper

1. Facilitate iton absorption
2. Stimulating the enzymes in the heme and/or glibin biosynthetic pathways
3. Mobilization of stored iron

39

Condition where there us an excessive copper storage in the liver

Wilson disease

40

Drug of choice to place the patient on negative copper balance

Chelating agent: penicillamine

41

Widely distributed in the body and assiciated with the metalloenzymes, lie alcohol dehydrogenase, lactic dehydrogenase and carbonic andmhydrase and carboxypeptidase

Zinc

42

Zinc is found where?

Meat, milk, fish, nuts and legumes

43

Improve or normalize the impaired glucose tolerance if sone diabetics, old people and malnourished children

Chromium

44

Antioxidant in conjuction with Vit. E

Selenium

45

As a sulfide, selenium is used jn the treatment of what?

Aeborrhea dermatitis

46

Widely used tiday for their anticariogenic action

Fluoride

47

Serves to cause a depression of the central nervous system in small doses. In large doses, depresses all reflexes and used as medication for epileptic seizures.

Bromide

48

A solution of arsenic trioxide and potassium used for leukemia because it lowers leukolyte counts

Potassium arsenite solution (Fowler's solution)

49

Depressant to the central nervous system and to circulation which in manic-depressive disorder.

Lithium

50

Used in rheumatism arthritis and lupus erythematosus

Gold

51

Are astringent and antiseptic and are used by cosmetic industry as deodorants

Soluble aluminum compounds

52

Protein precipitant. Ranges from anstiseptic, astringent, irritant to corrosive

Silver

53

Used as diuretics, antiseptic, parasiticide and fungicide.

Mercury

54

As a seductive

Strontrium bromide

55

Treatment of osteoporosis

Strontium lactate

56

Tooth temperature desentisizing agent

Strontium chloride

57

May result from ingesting painf chips of old houses by children

Lead poisoning

58

A phenomenon referring to magpie and its indiscriminate eating habits

Pica

59

Symptom of lead poisoning resulting to brain damage or mental retardation

Lead encephalopathy

60

Local Japanese disease caused by drinking water contaminated by cadmiun

Itai-itai