Flashcards in Chapter 42- Herpesviridae CMV and EBV Deck (10):
describe the characteristics of the Epstein Barr virus
double stranded DNA virus
What does the mono spot test check for?
The heterophiles Ab
Pathogenesis of EBV
disease is the result of viral replication and host response to viral Ag. EBV infects epithelial cells of the mouth and throat.
Cancers associated with EBV
1. Hodgkin lymphoma
2. Burkitt lymphoma
3. Nasopharyngeal carcinoma
4. Oral hairy leukoplakia
Describe an EBV infection
enlarged cervical nodes and splenomegaly. low grade fever with no extreme elevations in WBC
Describe an CMV infection
Cervical nodes;splenomegaly not as common. systemic symptoms and fever predominate.
Productive infection in epithelial cells acquired from blood, tissue, and most body secretions. Latency in monocytes, dendritic cells, megakaryocytic and myeloid progenitor cells.
Clinical presentation and DX of CMV
Heterophile Ab negative. CMV-specific IgM or 4 fold increase in CMV-specific IgG. IgM can be positive for months. Use amplification Assays.
Outcomes for CMV
1. Normal immunity- asymptomatic carrier. mono like illness
2. Baby (mom seronegative)- cytomegalovirus inclusion disease with CNS disease.
3. AIDS and immunosuppressed- multisite symptomatic disease