Chapter 42- Herpesviridae CMV and EBV Flashcards Preview

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Flashcards in Chapter 42- Herpesviridae CMV and EBV Deck (10):
1

describe the characteristics of the Epstein Barr virus

double stranded DNA virus

2

What does the mono spot test check for?

The heterophiles Ab

3

Pathogenesis of EBV

disease is the result of viral replication and host response to viral Ag. EBV infects epithelial cells of the mouth and throat.

4

Cancers associated with EBV

1. Hodgkin lymphoma
2. Burkitt lymphoma
3. Nasopharyngeal carcinoma
4. Oral hairy leukoplakia

5

Describe an EBV infection

enlarged cervical nodes and splenomegaly. low grade fever with no extreme elevations in WBC

6

Describe an CMV infection

Cervical nodes;splenomegaly not as common. systemic symptoms and fever predominate.

7

Cytomegalovirus

Productive infection in epithelial cells acquired from blood, tissue, and most body secretions. Latency in monocytes, dendritic cells, megakaryocytic and myeloid progenitor cells.

8

Clinical presentation and DX of CMV

Heterophile Ab negative. CMV-specific IgM or 4 fold increase in CMV-specific IgG. IgM can be positive for months. Use amplification Assays.

9

Outcomes for CMV

1. Normal immunity- asymptomatic carrier. mono like illness
2. Baby (mom seronegative)- cytomegalovirus inclusion disease with CNS disease.
3. AIDS and immunosuppressed- multisite symptomatic disease

10

Roseola

Caused by HHV 6 and 7. fever first, then rash later. generally uncomplicated and mild.