Flashcards in Chapter 44 - Cardiotonic Agents Deck (8):
What is Digoxin?
Cardioglycoside for the treatment of...
2. Atrial Fibrillation
What are the actions of Digoxin?
Increases intracellular Ca+ and allows more Ca to enter the myocardial cell during depolarization causing a positive inotropic effect.
Increased Renal perfusion with a diuretic effect and decreased renin release, a negative chronotropic effect (slower HR), slowed conduction through the AV node.
What are the adverse effects of Digoxin?
DONT TAKE WITH POTASSIUM LOSING DIURETICS
Contraindications of Digoxin?
1.Ventricular Tachy or V fib. (should be treated with something else)
2. Heart block or sick sinus syndrome
3. Idiopathic hypertrophic subaortic stenosis (IHSS)
4. Acute MI
5. Electrolyte Imbalances
DIGIFAB USED TO TREAT DIGOXIN TOXICITY
What is Milrinone?
Phosphodiesterase Inhibitor that is for the treatment of...
1. HF for PT who have not responded to digitalis, diuretics, or vasodilators.
Actions of Milrinone?
Blocks the enzyme phosphodiesterase, which leads to increase in myocardial cell cAMP, which increases Ca+ levels in the cell, causing a stronger contraction and prolonged response to sympathetic stimulation; directly relaxes vascular smooth muscle.
Adverse effects of Milrinone?