Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Immunology > Chapter 5 > Flashcards

Chapter 5 Flashcards

Antigen Recignition by T Lymphocytes (63 cards)

Start Studying
1
Q

Is TCR similar to BCR

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what does TCR have that BCR does now

A

alpha chain beta chain that does antigen binding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

does tcr have a transmembrane region

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

the red part on the t cell binds both what

A

MHC and peptide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

does TCR undergo VDJ recomincation

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are the two classes of t-cell receptor

A

alpha beta
gamma delta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

gamma is equivalent to alpha which is equivalent to

A

light chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

delta is equivalent to beta which is equivalent to

A

heavy chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

where is the delta chain located on tcr

A

in between v and j

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

if the alpha chain starts the process it kicks out what chain entirely

A

delta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what do gamma delta tcrs bind

A

glycolipids presented by CD1 molecules instead of peptides presented on MHC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

are b cells or t cells more diverse

A

t cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

total diversity is added afterwards with what

A

somatic hypermutation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TCR=

A

binding domain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the signal domain

A

CD3 and zeta chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

do you need both zeta and CD3 to work

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

major histocompatibility complex genes encoded in the

A

human leukocyte antigen locus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

the whole region is

A

HLA locus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

class II HLA involves what

A

MHCII and other genes involving Ag processing and presentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

class I HLA encodes what

A

MHCI genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

MHCI is on all

A

nucleated cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

are red blood cells nonucleated

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

what is present to CD8 and T cells

A

MHCI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

what helps with intracellular infection/ antigens

A

MHCI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
in MHCI Ag are broken down in
cytoplasm
26
professional Ag- presenting cell is what complex
MHCII
27
MHCII recognizes what
B cells macrophages dendritic cells
28
what is present to CD4 (helper) T cells
MHCII
29
what has antigens from extracellular infections
MHCII
30
in MHCII Ag are broken down in
endosomes (phagosome)
31
TCRs bind both what
MHC and antigen
32
CD T cell recognizes viral antigens presented by ...
MHC class I on virus-infected cell
33
CD8 T cells does what to the virus-infected epithelial cell
kills
34
CD4 T cell recognizes bacterial antigens presented by...
MHC class II on a macrophage
35
what does CD4 T cell secrete that activate the macrophage, increasing its capacity to kill bacteria
cytokines
36
CD4 T cell recognizes bacterial antigens presented by MHC class II on a
B cell
37
CD$ T cells secretes cytokines that drive the differentiation of the B cell into a....
plasma cell making bacteria-specific antibodies
38
39
Co- receptors bind what domain of MHC molecules
Ig-like
40
target cell of CD8 T cell binds
alpha 3
41
antigen presenting cell of CD4 T cell binds
beta 2
42
emoty MHC molecule has what kind of binding
promiscuous
43
what does promiscuous binding mean
MHC molecule bind in non-sequence specific manner which binds multiple peptides
44
MHC class I and bound peptide has what kind of conformatioin
closed
45
does MHC class I and bound peptide have open or closed ends
closed
46
what is the limit size of mhc class I and bound peptide
8-10 aa
47
MHC class I and bound peptide has anchor residues at 2/9 of peptide and these bind
2 a.a. on MHC in groove
48
MHC class II and bound peptide has what type of conformation
open ends
49
length of MHC class II and bound peptide
10-25 a.a. in length
50
about how many a.a in groove and where do the rest go?
about ten a.a. and the rest hang over
51
how many residues of the peptide that bind a.a. in the groove
3-4
52
basic antigen processing and presentation MHC I
1. Ag in cytoplasm 2. breakdown antigen 3. load into MHC 4. present peptide to a T cell
53
basic antigen processing and presentation MHC II
1. Ag taken up 2. break down Ag 3. Ag loaded onto MHC II
54
in basic antigen processing and presentation MHCII, antigen is taken up from extracellular space into
intracellular vesiscles
55
in basic antigen processing and presentation MHCII, in early endosomes of neutral pH, what are inactive
endosomal proteases
56
in basic antigen processing and presentation MHCII, acidification of vesicles activates proteases to degrade antigen into
peptide fragments
57
in basic antigen processing and presentation MHCII, vesicles containing peptides fuse. with
vesicles containing MHC class II
58
3 steps in AG for NHC I antigen processing and presentation
1. cell infected 2. Ag will be broken down by immunoproteosome 3. TAP will transport peptides from cytoplasm to ER
59
3 steps in MHC for MHC I antigen processing and presentation
1. MHC is translated and sent to the ER 2. MHC assemble w/ calnexin as chaperone from beta-2 microglobin 3. MHC assembles the peptide loading complex MHC+ calreticulin+ tapasain+ ERP57
60
step, 4,5,6, for MHC I antigen processing and presentation
4. peptide loading complex sample peptides that enter ER-> pick peptide that is good fit 5. ERP57 will trim the peptide down to 8-10 aa 6. MHC and peptide will get secreted to cell surface
61
what is immunoproteosome induced by
IFNdelta
62
what do immunoproteosome generate
peptides that are 8+ aa w hydrophobic basic a.a. @ c terminus
63
what does ERP57 do
trim

Immunology (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions