Chapter 66 - Bioengineered vascular grafts

Question 1

Artegraft

Answer 1

Bovine arteries stripped of parenchymal protein –> decellularization tubular prosthesis composed mostly of collagens

Question 2

Procol

Answer 2

Bovine mesenteric veins decllularized and fixed with glutaraldehyde cross-linking and gamma radiation high in elastin

Question 3

Venous cryo graft are better than arterial cryo graft because

Answer 3

arteries rely on vasa vasorum which are destroyed by cryo process

Question 4

Biohybrids

Answer 4

luminal modification to coat endothelial cells and vascular smooth muscles cells into grafts

Question 5

Tissue engineered vascular grafts

Answer 5

cellular/tissue based vascular conduits synthetic component to degrade overtime to be replaced by autogenous tissue

Question 6

Three categories of tissue engineered vascular grafts (TEVG)

Answer 6

1) bioreactors: grafts created in vivo 2) scaffold-based 3) sheet-based

Question 7

Omniflow

Answer 7

glutaraldehyde-tanned ovine collagen tube grown around Dacron mesh in sheep bioreactor type of bioractor

Question 8

Scaffold-based TEVG

Answer 8

Scaffold with adventitial fibroplasts, collagen and SMC mounds around dacron still can get infected Biodegradable scaffolds use L-lactide and E-caprolactone with polyglycolic acid fabric

Question 9

Suture strength, burst pressure and compliance of various conduits

Answer 9

TABLE 66.1

Question 10

Isolated vessels and tissue-engineered vascular tubes comparison of preparation, patency and complication

Answer 10

TABLE 66.2