CHAPTER: Immuno Flashcards Preview

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Flashcards in CHAPTER: Immuno Deck (28):
1

Mutation, presentation, findings XL agammaglobulinemia

X BTK = X tyrosine kinase = X B cells
**NO Abs (vs CVID with ↓Ig)
> 6 mo, bacterial (IgG), entero + Giardia (IgA) infections
No LNs or tonsils

2

Presentation, findings IgA def

Mucosal infections
Normal IgG + IgM
If Celiac pt has IgA def - IgG will cause derm hepetiformis

3

Presentation, findings, complications CVID

Only affects B cells: ↓Ig of all classes (low not no Abs)
Same problem as AL-Agamma:
1. X IgG: bacterial
2. X IgA: entero + Giardia
↑AI + lymphoma

4

Mutation, presentation, findings AD hyper IgE syndrome (Job)

STAT 3 mutation -> X Th17 cells (type Th)
↓Neutrophil to infection sites
↑IgE
**Retained primary teeth**
Abscess are cold - no neutrophils!

5

Mutation, presentation, findings ataxia telangiectasia

ATM gene -> bad DNA repair
1. Ataxia (cerebellar atrophy) + telang
2. ↓ IgA, G, E
3. ↑AFP

6

What T cell disorder might present after BGC admin?

IL 12 R def = AR
If can't bind IL 12, ↓Th1 --> ↓IFNg

7

3 causes of SCID

1. ADA def (AR)
2. IL 2 R defect (XL)
3. MHC 2 def = bare lymphocyte syndrome

8

2 immunodef w/ absent thymic shadow

DiGeorge - X thymus or PT - no T cells
SCID - no thymus or germinal centers in LNs

9

Mutation, presentation, findings hyper IgM

XL recessive - no CD40L
Can't class switch B cells after binding Th
Only IgM

10

Mutation, presentation, findings Wiskott Aldrich

XL recessive WAS gene
T cells can't bind cytoskeleton
WATER
Wisckott
Ald
TCP
Eczema
Recurrent infection: ↑IgE, A

11

Disease w/ delayed umbilical cord sep

LAD - no integrins = can't bring neutrophils into infection sites
*No CD 18 = integrins*
↑neutrophils in blood (lose the marginated pool in lungs)

12

Disease presenting with:
1. Albinism
2. Peripheral neuropathy
3. Infection

Chediak Higashi
MT problem
Giant cells in blood cells @ bone marrow biopsy (pancytopenia b/c nothing can get out)

13

What T cell mediated acute vs chronic transplant rejection

Acute: CD 8
Chronic: CD 4

14

Lung, heart, kidney, and liver presentation of chronic rejection

Lung = bronchiolitis obliterans
Heart = faster atherosclerosis
Kidney = nephropathy
Liver = obliterate bile duct

15

Post blood transfusion pt has low BP, flank pain, hemoglobinuria, and jaundice - what is going on?

You gave them the wrong ABO
*Acute hemolytic transfusion rxn*
Intra + extravas hemolysis
T2 HST

16

Post blood transfusion pt has low BP, bronchospasm, shock

You can IgA def pt blood with IgA in serum
*Anaphylaxis* + epi

17

Post blood transfusion pt has fever, headache, chills - what is going on?

Febrile non-hemolytic transfusion rxn
T2 HST - host Ab vs donor HLA (even though properly matched)

18

What is the arthus rxn

T3 HST
You inject antigen into skin - person has IgG against that
Deposit of ICs -> edema, necrosis, complement activation

19

Difference between Salk and Sabin vaccine

Salk = sulky goth teen - killed vaccine
Sabin = live attenuated

20

What does pyocyanin of pseudomonas do?

Make ROS to kill competing microbes

21

What does lactoferrin do?

In secretory fluids + neutrophils
X microbes by chelating Fe that the bugs need to survive

22

2 substances released that mediate pain vs fever

Pain: PGE2 + bradykinin
Fever: IL1 + TNF -> ↑PGE2 @ hypothalmus

23

What is the Hageman factor? 3 pathways it activates

= F7, activates:
1. DIC
2. Kinin -> bradykinin
3. Complement

24

Describe 3 steps of antigen indep Ab diversity

1. Recomb
VJ = light chain
VDJ = heavy chain
2. Tdt randomly adds nucleotides
3. Random combo of heavy + light chains

25

Name 2 steps of antigen dep Ab diversity

1. @ variable region = SHM + affinity maturation
2. @ constant region (Fc) = isotype switching

26

2nd signal for CD4 or 8 T binding dendritic cell

CD 28 // B7

27

2nd signal for Th + B cell binding

CD 40 / CD 40 L
Without - hyper IgM

28

Where is the antigen loaded onto MHC 1 vs 2 in the cell?

MHC 1 @ RER after delivery via TAP
MHC 2 = after invariant chain release from acidified endosome