Chemo Drugs Flashcards Preview

CSO 2018 > Chemo Drugs > Flashcards

Flashcards in Chemo Drugs Deck (115):
1

CYP3A4 inducers May decrease drug activity for example St John's wort and

Also avoid CYP3A4 inhibitors which may increase drug activity, for example and grapefruit juice , Ketoconazole, and erythromycin be

Axinib (Inlyta) take two times a day, 12 hours apart.
Bortezomib ( velcade)
Exemestane (Aromasin) take after a meal
Dasatinib (Sprycel) don't crush
Erlotinib (tarceva)
Lapatinib( Tykerb) take on an empty stomach. One hour before or two hours after meals. Take same time everyday with a full glass of water

Everolimus (Afinitor) take same time each day
Tamoxifen (nolvadex) take same time each day
Imatinib mesylate (Gleevec) take with a meal
Sunitinib (sutent)
Sorafenib (Nexavar)

2

Bexarotene (Targretin)

GRAPEFRUIT JUICE juice may increase concentration and

LIMIT VITAMIN A intake to greater than or equal to 1,500 IU per day to avoid possible ADDICTIVE toxicity with this drug

Take as a single dose with food.

CLUE: The XA ="A"ddictive in Bexarotene ; "Targret" for less than 1500 IU and to avoid grapefruit juice to be safe

3

Bortezomib ( velcade)

Green tea should be avoided while taking this drug, especially in liquid and capsule forms.

CYP3A4 Inhibitors or inducers may alter this drug activity so monitor closely

Drug can be taking intravenous or subcutaneously

Clue: zombies are green

4

Busulfan (Myleran)




Side effects are nausea, diarrhea, vomiting, MUCOSITIS

Avoid aspirin while taking this drug

This drug should be taken on an empty stomach.

For chronic leukemia

Clue: bufferin is an aspirin Myleran , M= mucositis

5

Capecitabine (Xeloda)

Side effects are nausea vomiting and diarrhea and myelosuppression and hand foot syndrome

Altered coagulation may happen when taken with Warfarin so monitor closely.

Vitamin B6 (a dose of 50 to 100 mg, 2 to 3 times a day) may help to prevent or reduce the incidence and severity of hand-foot syndrome.

Clue: tell Bill to take a Loda his feet or could get blood clots..

Take this drug within 30 minutes of a meal with a full glass of water.

Colon and metastatic breast cancers

6

Cetuximab (Erbitux)

Side effects are nausea vomiting diarrhea and constipation. LOW MAGNESIUM

Monitor magnesium (1.5-2.4) and calcium (8.5-10.2) levels closely.

At-risk population are elderly people who have hypomagnesemia at Baseline, and patients who have received prior treatment with oxaliplatin (Eloxatin)

Monoclonal antibodies/ EGFR

Clue: the peanut character wears a tux. Most nuts are a good source of calcium and magnesium. But peanuts are low in calcium and magnesium. So we would need to monitor these levels in the peanut character to keep his bones strong . And those with colorectal and head and neck cancers should not eat peanuts

Drug for cancers o fColorectal and head and neck

7

Chlorambucil (leukeran)

Side effects include nausea, vomiting, hyperuricemia (elevated Uric acid in the blood)

There is a risk of toxicity if barbituate have been taken

Take this drug on an empty stomach, either one hour before meals or two hours after meals

Used for pancreatic cancer

8

Cisplatin (platinol)

Side effects are: nausea, vomiting , METALLIC TASTE and kidney toxicity, LOW MAGNESIUM, Peripheral neuropathy, loss of appetite, taste changes( taste like Platinum)

HYDRATION IS IMPORTANT to prevent nephrotoxicity, MAY NEED IV FLUIDS

Carefully monitor renal function or, <7 BUN ; .
<0.6w or <0.8m creatinine, <1.5 magnesium ,<8.5 calcium, <135 sodium and <3.5 potassium levels.

At-risk elderly, renal pts, and those with hypomagnesemia

OMEGA 3 & TURMERIC & milk thistle ENHANCES BENEFITS

Bladder, cervical, esophageal, head and neck, lung, ovarian,prostate, testicular

9

Dasatinib (Sprycel)

Type of cancer?

Avoid St John's wort and phenobarbital which may decrease drug activity

Avoid grapefruit juice ketoconazole and erythromycin which may increase drug activity

Do not crush or cut drug

10

Deferasiox ( Exjade)

Type of cancer?

If this drug is not fully dissolved it can cause diarrhea

This drug contains lactose. So it may cause diarrhea in lactose intolerant patients

Recommend lactase enzyme supplement with dosing

Dissolve tablets completely in water before taking

Clue: you must try to get the patient to DEFER to using SOIX milk instead of cow milk because this product contains LACTOSE which causes DIARRHEA. If the patient uses this product they must also use a LACTASE ENZYME supplement and completely DISSOLVE this and water before taking it to avoid diarrhea.

11

Erlotinib ( tarceva)

SIDE EFFECTS nausea, vomiting, diarrhea, low appetite, hand-foot syndrome and rash

NO St John's Wort or phenobarbital, grapefruit juice or erythromycin

Take on an empty stomach either one hour before meals or two hours after meals. Take same time everyday with a full glass of water.

for pancreatic & lung ca

Tyrosine kinase inhibitor ; targets inside of cell

Clue; Tarzan lives in the jungle where he often has empty stomach for lack of food. Which often causes him nausea vomiting diarrhea rash and Lou appetite. He also uses his hands and feet swing around the jungle. With limited food he eats same time every day and drinks plenty of water.

12

Everolimus ( afinitor)

Type of cancer?

Drug activity May decrease if taken with st. John's Wort or phenobarbital

Drug activity may increase of taking with grapefruit juice or erythromycin

Do not chew or Crush

Take once a day at the same time

13

Fluorouracil ( 5-fu)

Side effects: nausea, vomiting, diarrhea, mucositis

Have patient melt ice chips in their mouth 10 to 15 min pre and post IV infusion to reduce chances of mucositis

Hand -foot syndrome is common, use B6 supplements (50 to 100 mg, 2 to 3 times a day) to avoid this

Clue: it has 5 side effects, nausea, vomiting ,diarrhea mucositis, hand-foot syndrome
(5FU) F=foot, U= u love ice for mUcositis

Breast, colorectal, GI, head and neck, pancreatic, and ovarian

Anti-metabolite, cell cycle specific

14

Imatinib mesylate (Gleevec)

G i s t

This is a protein targeted therapy

Side effects include, rash, hand-foot syndrome, nausea and vomiting, diarrhea, poor appetite, hair turns White

Avoid St John's wort and grapefruit juice

15

Lapatinib ( Tykerb)

Drug activity may increase if grapefruit juice or erythromycin are

Do not chew or crush

Take on an empty stomach either one hour before meals or two hours after meals and take with a full glass of water

Clue: Lapatinib ( TykErb) E= empty stomach

16

Melphalan (Alkeran)

Side effects include nausea, vomiting, diarrhea, and mucositis

Premedicate with an anti-nausea medication 1 hour before the dose of this medication

Encourage small frequent meals and snacks

Take on an empty stomach either one hour before meals or two hours after meals

Alkylating agent for Breast, & ovarian cancers
Women's cancers... for Mel(anie) & Keran

Clue: MelphalaN (Alkeran) M= mucositis, N=nausea(premedicate, small frequent meals, and empty stomach)

17

Mercaptopurine (6- MP)

Side effects include nausea, vomiting, diarrhea and mucositis and hyperuricemia

Avoid consuming Dairy containing foods when taking

Take on an empty stomach 1 hour before meals or two hours after meals

Leukemia's

Clue: Mercaptopurine, M=mucositis
MP or military police can't do dairy unless it's on an empty stomach or they'll get diarrhea, nausea vomiting mucositis and hyperuricemia

18

Methotrexate, Folex or Rheumatrex (MTX)

Side effects include nausea, mucositis oral and Gi ulcerations, sensitive to light

Avoid folic acid & alcohol

Take on an empty stomach either one hour before or two hours after meals
Clue: even though you must avoid the sunlight, DON'T TREXs the strip at Carbondale for ALCOHOL & if you sleep around and get pregnant DON'T do FOLIC ACID or you will get nausea oral and GI sores and mucositis
Bladder, breast, and neck
You

19

Nilotinib ( Tasigna)

Grapefruit juice may increase drug

This drug contains lactose so lactose intolerant patients May experience diarrhea

Recommend lactase enzyme supplement with dosing

Take on an empty stomach with water

20

Oxaliplatin (Eloxatin)

Side effects include nausea , vomiting, diarrhea, sensitivity to cold, hand- foot syndrome

Minimize exposure to cold for up to 5 days after the infusion by avoiding handling, eating and drinking cold or frozen foods. Sensitivity to cold May persist for longer periods of time with subsequent dosing

CLUE: he loxs the refrigerator to avoid eating cold food, and getting nausea vomiting diarrhea and cold hands and feet

Vitamin B6, a dose of 50 to 100 mg, 2 to 3 times a day, may help to prevent or reduce the severity of hand-foot syndrome

Colorectal, pancreatic, gastroesophageal cancers

This is an alkylating agent, cell cycle non specific

21

Panitumumab (Vectibix)

Side effects are diarrhea (in the bed pan) and fatigue

Can cause low magnesium, Monitor magnesium levels
Clue: PanituMUMab = MagnesiUM

At-risk are the elderly and patients with low magnesium

For colorectal cancer

Is a monoclonal antibody / EGFR

22

Pemetrexed (Alimta)

Side effects include nausea, vomiting, diarrhea and fatigue, SEVERE ANEMIA
Clue: Pemetrexed (AlimtA)= AnemiA

To prevent possible SEVERE ANEMIA:

-Folic acid, 350-1000mg, orally should be started at week one before the first treatment daily throughout treatment and post-treatment

-vitamin B12 (1000 mg) injections should be given every three Cycles beginning week one before the first treatment and continually through treatment

For lung cancer and mesothelioma

23

Procarbazine Hydrochloride ( Matulane)

Side effects are CONSTIPATION, diarrhea, DRY MOUTH

Follow a low tyramine diet when on this and for two weeks after. Tyramine Foods include ALL CAFFEINE AND ALCOHOL, beer, red wine, Sherry, distilled Spirits, brewer's yeast, Fava beans, raspberries, figs, dried fruits,( raisins and prunes,) avocados, bananas, miso soup, soy sauce, sauerkraut, aged or strong cheese ( cheddar, gruyere, manchego, Gouda, blue, parmesan), anchovies and caviar, beef and chicken livers, meat extract, meat such as sausage, bologna, pepperoni, and salami.
USED FOR BRAIN TUMORS

24

Regorafenib (Stivarga)

Side effects include anorexia, nausea and vomiting, diarrhea, and mucositis of COLON CA TX

High-fat meals can alter the absorption of drug

Take meals in the morning with a low fat meal that contains less than or equal to 8 grams of fat

Clue: RegoraFenib (Stivarga)= F=low fat (8 letters=8g)

25

Spiuleucel- T (Provenge)

Avoid caffeine on the day of leukapheresis

Drink more water than usual on the day of treatment

Consume a calcium rich breakfast prior to receiving this treatment

Clue; SpiuleuCel- T =C = avoid Caffeine/eat Calcium

A vaccine for prostate cancer

26

Streptozocin (Zanosar)

Not sure what type of cancer used

This drug Alters glucose metabolism, or causes HYPOglycemia, and some patients.

This drug is given intravenously

Clue: Streptozocin (ZanosAR)= SugAR

Torisel causes HYPERglycemia

27

Sorafenib (Nexavar)

Used for liver or kidney ca

Side effects include anorexia, nausea and vomiting, diarrhea , hand-foot syndrome, rash, White hair

Avoid St John's Wort, phenobarbital, and dexamethasone as they may decrease drug activity

Take on an empty stomach, either one hour before meals or two hours after meals

Take with a full glass of water

This is a protein targeted therapy, Tyrosine Kinase inhibitor; it targets inside cell

28

Sunitinib (Sutent)

GIST, renal cell cancer, pancreatic neuroendocrine tumor

This is a protein targeted therapy, Tyrosine Kinase inhibitor; it targets inside cell

Side effects are nausea, vomiting, diarrhea, poor appetite, hand-foot syndrome, rash, hair turns white.

Avoid st. John's Wort and phenobarbital as it may decrease drug activity

Avoid grapefruit juice, Ketoconazole, and erythromycin is it may increase drug activity

29

Tamoxifen (Nolvadex)

Anti estrogen agent for breast cancer

Side effects include hot flashes, nausea, vomiting, weight gain, fluid retention, peripheral edema

Avoid st. John's wort and phenobarbital

Avoid grapefruit juice, Ketoconazole and erythromycin

Avoid antacids within 2 hours of taking the drug

Take at the same time each day

Flaxseed May enhance the efficacy of tamoxifen

30

Temsirolimus (Torisel)

Not sure for what cancer

Can cause hyperglycemia

Can cause hyper cholesterol

Streptoz (Zanosar) causes hypoglycemia

31

Temozolomide (Temodar )

For glioblastoma

Side effects include nausea, vomiting, fatigue, headache, photosensitivity, rash

Take at bedtime or on an empty stomach the full glass of water

Do not chew or Crush

Alkylating agent; cell cycle, nonspecific drug

32

Thalidomide (Thalomid )

Causes constipation, nausea and xerostomia or dry mouth

Drug interactions with barbiturates, chloropromazide and reserpine.

Avoid alcohol

Take at bedtime or after the evening meal

Used for graft-versus-host disease in Hematopoietic Cell Transplantation patients

Angiogenesis inhibitor

33

Vinblastine (Velban)

Breast, testicular, head and neck cancers

Side effects include mucositis, stomatitis,
SEVERE constipation, hypertension, JAW PAIN

Use stool softeners or laxatives to help prevent severe constipation

Avoid St John's Wort , dexamethasone and grapefruit juice

Clue: may need stool softeners to BLAST away the SEVERE constipation

34

Vincristine (Oncovin)

Leukemia, lung cancer, neuroblastoma , Ewing's sarcoma, Wilms sarcoma, brain and thyroid cancer

Side effects are Severe Constipation, and jaw pain, decreased appetite
To avoid severe constipation take stool softeners and or laxatives

Omega-3 fats - May enhance clinical benefit
Avoid St John's Wort, phenobarbital, dexamethasone
Avoid grapefruit juice, Ketoconazole, and erythromycin

This is a vinca alkaloid

35

Zoledronic Acid (Zometa )

Given for bone metastases or bone pain

Patient should take an oral supplement of 500 mg of calcium and 400 IU of vitamin D daily when taking this medication

This is given intravenously

36

Side effects of Monoclonal Antibodies, or chemotherapy that targets outside the cells

Infusion related symptoms: fever, chills, fatigue
Gastrointestinal: nausea, vomiting, diarrhea. Mild.
Cardiotoxicity: Despina and peripheral edema
Myelosuppression
Pulmonary toxicity
Skin rash and hand-foot syndrome

37

Side effects of Protein Targeted Therapies, or chemotherapy that targets INSIDE the cell

Nausea, vomiting, diarrhea and poor appetite
Rash
Hand-foot syndrome
Cardiotoxicity
Hair turns White
Hypertension
Bleeding

38

Names of Protein Targeted Therapies, or chemotherapy that targets INSIDE the cell

Erlotinib or tarceva
Gefitinib or Iressa
Imatinib or Gleevec
Sorafenib or Nexavar
Sunitinib or Sutent
Temsirolimus or Torisel
Everolimus Affinitor
Bortezomib or Velcade

39

Examples of Monoclonal Antibodies, or chemotherapy that targets outside of the cell

Cd20, Ibritimomab (Zevalin)
Cd20, Rituximab ( Rituxan)
Her 2 Neu, Pertuzumab ( Perjeta)
Her 2 Neu, Trastuzumab ( Herceptin)
Her 2 Neu, Ado- Trastuzumab (Kadcyla)
EGFR, Cetuximab (Erbitux)
EGFR, Panitumumab (Vectibix)
RANKL, Denosumab (Xgeva)
RANKL, Denosumab (Prolia)

40

What do angiogenesis Inhibitors type of chemotherapy do

They hinder the formation of new blood vessels

41

What are the possible side effects of Angiogenesis Inhibitor type chemotherapy?

Hypertension
Heart attack, angina, stroke
Protein urea, especially with bevacizumab
Bleeding
GI perforation
Hypothyroidism…
VEGF, Bevacizumab (Aviston)
Lenalidomide (revlimid)
CLUE:
Matt's brother lives in Aviston. He has a pig farm. Eating pigs gives these side effects eggs are a protein. you poke a pig

42

What are examples of Angiogenesis Inhibitor type chemotherapy

VEGF, Bevacizumab (Aviston) - proteinuria is common
Lenalidomide (revlimid)
Thalidomide

43

What are cytokines

A type of biotherapy chemotherapy that stimulates a broad-based immune response

44

What are the possible side effects of cytokines

Flu like symptoms like fever, chills, headache arthralgias and myalgias
Fatigue and anorexia
Anemia
Nausea, vomiting and diarrhea
Renal insufficiency and CAPILLARY LEAK SYNDROME

45

What are examples of Cytokine Therapies?

Interleukin-2 or IL-2 (Aldesleuken)

Interferon-a (Roferon or Intron A)

46

What are examples of selective estrogen receptor modulators or anti estrogens?

These are hormonal agents

Tamoxifen citrate or nolvadex
Toremifene citrate or Fareston
Raloxifene or Evista

The first two are used for breast cancer
Third is used for osteoporosis or postmenopausal women at risk for breast cancer

Side effects include hot flashes, sweating, nausea, vomiting, weight gain, fluid retention

47

What are examples of the hormonal agents called aromatase inhibitors?

Anastrozenole or Arimidex
Letrozole or femara
Exemestane or Aromasin

These drugs are used for breast cancer

48

What are the side effects of aromatase Inhibitors used for postmenopausal breast cancer

Hot flashes
Mild nausea and vomiting
Blood clots
Fever and fatigue
Joint and muscle aches and pains

High cholesterol with Letrozole

These cause bone loss so take calcium and vitamin D if deficient

49

What are examples of hormonal agents called Progesterones and their side

Megace

Side effects include
Weight gain, blood clots, nausea and vomiting, hot flashes, mood changes, hyperglycemia

For breast cancer, endometrial, renal cell and an appetite stimulant

50

What are examples of hormonal agents called anti-androgens and what are the side effects andwhat types of cancers are they used for?

Bicalutamide (Cadodex)
Flutamide (Euladex)

Used for prostate cancer

Side effects include weight gain, hot flashes, fatigue, decreased libido, impotence and bone pain

51

What are examples of hormonal agents called LHRH luteinizing hormone-releasing hormone and Agonists? What are there side effects and what type of cancer are they used?

Leuprolide acetate ( Lupron)
Groserelin (zoladex)

Used for prostate cancer

Side effects include hot flashes, fatigue, decreased libido, bone pain, gynocomastia, headache and muscle weakness

52

What are cancer vaccine Therapies?

Unlike targeted Therapies these are designed to stimulate an individual's own immune system against abnormal foreign cells such as cancer cells

Today only one cancer vaccine is approved for use in men for metastatic prostate cancer and it is called

sipuleucel -T (Provenge)

53

Ado- Trastuzumab (Kadcyla)

Main nutritional side effect is constipation

It is for metastatic breast cancer

It is a monoclonal antibody /her 2 Neu

54

Gefitinib ( Iressa)

Side effects include nausea, vomiting, diarrhea, low appetite, hand-foot syndrome, rash.

For refractory non small-cell lung cancer

This is a protein targeted chemo that targets the inside of a cell . A tyrosine kinase inhibitor

Important to take with water!

55

Tyramine foods include:

Tyramine Foods include ALL CAFFEINE AND ALCOHOL, beer, red wine, Sherry, distilled Spirits, brewer's yeast, Fava beans, raspberries, figs, dried fruits,( raisins and prunes,) avocados, bananas, miso soup, soy sauce, sauerkraut, aged and strong Cheese's, anchovies and caviar, beef and chicken livers, meat extract, meat such as sausage, bologna, pepperoni, and salami.

56

Bendamustine (Treanda)

Side effects include nausea, vomiting fatigue, TUMOR LYSIS SYNDROME

For lymphoma and leukemias

This is an alkylating agent

57

Carboplatin (Paraplatin)

Side effects include nausea and vomiting, peripheral neuropathy

Used to treat bladder, endometrial, head and neck, lung, and ovarian

This is an Alkylating agent

Clue: can't drive the CAR because you can't feel the feet or hands

58

What is the normal lab level for BUN?

7 - 22 m Eq.

There is a concern if greater than 50 without renal insufficiency

This lab indicates hydration status and renal function

Decreased levels indicate starvation and low protein
Elevated levels indicate dehydration and high protein intake

59

What is the normal lab level for creatinine?

Creatinine is a good indicator of kidney function
0.8-1.2mg/dL in males
0.6- 1.0 mg/dL in females
Concern if greater than 2 - 2.5
Increased levels indicate renal failure and muscle atrophy

60

What is the normal lab level for magnesium?

1.5-2.4 mEq/L

Elevated levels May indicate renal failure or excess intake of antacids

Decreased levels May indicate malabsorption, diarrhea, refeeding syndrome

61

What is the normal lab level for calcium?

8.5-10.2 mg/dL

Elevated levels May indicate metastatic cancer

62

Normal lab levels of sodium?

135-145mEq
Critical values greater than 160

63

Normal lab values for potassium?

3.5-5.0

This gives us a clue about renal function and is a potential clue for irregular heartbeat

Signs and symptoms of low potassium are cramps low blood pressure and low GI function

64

What are the normal lab values for hemoglobin?

14-18 for men

12-16 for women

Elevated level dehydration

Decreased level anemia, blood loss, cancer

65

What are the normal lab values for hematocrit?

40-52 % for males
37 to 47% for females

Elevated levels indicate dehydration
Decreased levels indicate anemia blood loss and cancer

Hematocrit levels should be a packed proximately 3 times greater than hemoglobin levels

66

What are the appropriate lab values for white blood cells?

4.1 to 10.9

Below normal range could be deficiency of vitamin B12 or iron

Above normal range could be dehydration

67

What is the appropriate lab value for a red blood cell count?

4.7 to 6.1m/Eq in men

4.5 to 5.4 m/Eq in women

Low range maybe anemia, deficiency of iron or B12 or renal disease

Above normal range severe dehydration or diarrhea

68

Denosumab (Xgeva)

Side effects are nausea, vomiting, diarrhea, LOW CALCIUM, OSTEONECROSIS (bone death)OF THE JAW

CLUE: If X g(or jaw) you must not be chewing calcium foods

This drug is for bone mets

Monoclonal antibody,RANKL,

69

What drugs are used for Acute nausea and vomiting?

Zofran
Anzemet
Kytril
Aloxi

These are serotonin antagonist

70

What drugs are used for chemotherapy - induced Vomiting

1) Decadron (dexamethasone) and Zofran plus Rezonic or Emend

2). Reglan

71

What drugs are used for
Delayed Nausea and Vomiting?

*Compazine or Phenergan. (Phenothiazines)

*Reglan ( a Benzamide)

* Marinol or Cesamet (Cannabinoids)

* Ativan or Valium. (Benzodiazapines)

*Decadron. ( a corticosteroid)


72

Which two drugs have hyperuricemia as a side effect?

Mercaptopurine (6-MP)

Chlorambucil (leukeran)

73

Which three drugs have low magnesium as a side affect?

Cisplatin (platinol)

Cetuximab (Erbitux)

Panitumumab (Vectibix)

Clue: peanuts (nuts) have magnesium... The peanut character wears a Tux (Erbitux) and comes from a "Plat" (plant)

74

With which drug should you avoid alcohol and folic acid?

Methotrexate MTX

Clue: when you tracks down the streets of Carbondale you need to watch out for drinking too much alcohol getting pregnant. And if you do need to make sure you take your folic acid.

75

Trastuzumab ( Herceptin)

Side effects are nausea, vomiting, diarrhea

Olive oil and Avocados May improve sensitivity of drug

Monoclonal antibody, Her 2 Neu,

Drug used for breast cancer and metastatic gastric ca

Clue: Laura HER loves to use OLIVE OIL and AVOCADO when cooking

76

Which drug has a side effect have sensitivity to cold food and drinks?

Oxaliplatin ( Eloxatin)
Minimize exposure to cold for up to 5 days after the infusion by avoiding eating and drinking cold or frozen foods.
Use care when handling cold or frozen foods from the refrigerator or freezer

CLUE: he loxs the refrigerator to avoid eating cold food

77

Azacitidine (Vidaza)

Side effects are LOW VITAMIN K LEVELS

Nausea, vomiting, diarrhea, and fatigue

ANTI-metabolites, cell psycho specific

Clue: Asa and K are friends

78

Which drugs have MUCOSITIS as a side effect?

Melphalan (Alkeran)
Fluorouracil (5-FU)
Busulfan (Myleran)
Thiothepa (Thioplex)
Cytarabine ( ARA-C)
Mercaptopurine (6-MP)
Methotrexate (MTX)
Thioguanine (6-TG)
Dactinomycin (Actinomycin)
Mitomycin-C (Mutamycin)
Daunorubicin ( Danomycin)
Doxorubicin (Adriamycin)
Doxorubicin ( Doxil)
Epirubicin (Ellence)
Idarubicin (Idamycin)
Etoposide (Vepesid)
Paclitaxel (Taxol) or( Abraxane)
Vinblastine (Velban)

Consume ice chips or a frozen ice pop during the administration of 5-fu and adriamycin

79

Which chemo drugs have hand foot syndrome as a side effect?

Fluorouracil 5FU
Doxorubicin (Adrimyacin)
Doxorubicin (Doxil)
Oxaliplatin ( Eloxatin)
Capecitabine (Xeloda)
Imatinib (Gleevec)
Sorafenib (Nexavar)
Sunitinib (Sutent)
Gefitnib (Iressa)
Erlotinib (Tarceva)

80

Which chemo drugs have constipation as a side

Vinblastine ( Velban)
Vinorelbine ( Navelbine)
Vincristine (Oncovin) severe; take laxatives
Ado-Trastuzumab (Kadcyla)
Procarbazine hydrochloride (Matulane)
Cetuximab ( Erbitux)
Thalidomide ( Thalomid)

81

Which drugs have metallic taste as a side effect?

Cisplatin (platinol) metallic taste( taste like Platinum)

Etoposide ( Vepesid)

Clue:. VESsel on the sea... POSeidon is the god of the sea... Men on Ancient vessels or ships had scurvy and this screwed up their TASTE

82

Etoposide ( Vepesid)

Side effects are METALLIC TASTE, anorexia, nausea, vomiting ,diarrhea, MUCOSITIS

DRUG USED FOR LUNG AND GASTRIC CANCER

83

Vinorelbine (Navelbine)

Side effects include CONSTIPATION, STOMATITIS anorexia, nausea and vomiting

Used to softener to avoid constipation

Clue: you are tummy (navel) is upset when you have constipation

This drug is used for breast, ovarian and lung CA

84

Olive oil can improve the sensitivity of which chemotherapy drugs?

Doxorubicin (Adrimyacin)
Cisplatin (platinol)
Vincristine ( Oncovin)
Paclitaxel (Taxol)
Trastuzumab (Herceptin)

85

Doxorubicin (Adrimyacin)

Side effects of this drug are mucositis, nausea and vomiting , diarrhea, hand-foot syndrome, anorexia, RED ORANGE URINE

OMEGA-3 AND COENZYME Q-10 and THEANINE in tea MAY DECREASE TOXICITY
Olive oil improves sensitivity, Theanine in tea enhances benefits

DRUG for breast, ovarian, liver, Lung, prostate, head and neck

Known as the Red Devil 4X red urine
Adriamycin,a=anorexia, d=diarrhea, m=mucositis

86

Doxorubicin liposomal (doxil)

Side effects include mucositis, nausea and vomiting, diarrhea, and foot syndrome, red orange urine

This drug is for ovarian cancer

87

Paclitaxel (taxol)

Side effects are diarrhea and mucositis

Omega 3s May reduce toxicity

Stay hydrated on this drug

This drug is for bladder, breast, ovarian, head and neck, esophageal, lung ,prostate ; pancreatic

Clue:" Pacs " of tuna in water may take the "tax" of toxicity off this drug

88

Cyclophosphamide (cytoxan)

Side effects include nausea and vomiting and bladder toxicity
Important to take with three liters of fluid per day and Instruct the patient to empty their bladder every 2 to 3 hours during the day and night to avoid bladder toxicity

If given a high dose, Mesna should also be given to prevent bleeding cysts.

This drug increases the effect of anticoagulants.

Take this drug earlier in the day
Clue; it is TOXIC TO THE BLADDER

This drug is for breast and ovarian cancers

89

Axinib (Inlyta)

CYP3A4 INDUCER decrease DRUG ACTIVITY WITH ST JOHN'S WORT AND PHENOBARBITAL AND MAY ALSO INCREASE DRUG ACTIVITY WITH GRAPEFRUIT JUICE

Take this drug twice a day but 12 hours apart

90

Thiothepa (Thioplex)

Side effects include nausea, vomiting, mucositis

Renal toxicity, rash, and bronzing of the skin

Treatment for bladder, breast and ovarian

91

Gemcitabine (Gemzar)

Side effects include nausea vomiting, pulmonary, flu like symptoms
May cause clay colored stool

4 bladder, breast, ovarian, pancreatic, lung
Most often used for pancreatic cancers

92

Mitomycin (mutamycin)

Side effects include nausea vomiting, mucositis, diarrhea, anorexia

Cancer of anus, bladder, breast, esophagus, head and neck, lung, pancreas and stomach

Clue: Mitomycin (mutamycin) M= mucositis

93

Epirubicin (Ellence)

Side effects include nausea, vomiting, diarrhea, mucositis

Skin rash and red orange urine

For breast in gastric cancer

Clue: Ellen is a girl, she has breasts / girls have red urine... Ellen is always "rub"bing her stomach because it is upset (nausea...)

Epi= skin rash

94

What drugs are used for ACUTE NAUSEA AND VOMITING?

Zofran
Aloxxi
Anzemet
Kytril

95

Which drugs cause HYPO MAGNESIUM ?

Cetuximab ( Erbitux)

Panitumumab (Vectibix)

Cisplatin (platinol)

96

Which drugs cause hypocalcemia and osteonecrosis of the jaw

Denosumab (xgeva)
Denosumab (Prolia)

97

Which drugs cause tumor lysis syndrome?

Rituximab (Rituxan)

Bendamustine ( Treanda)

Tumor lysis syndrome occurs when large numbers of cancer cells are killed rapidly, leading to the release of byproducts into the circulation. Can cause hyperuricemia,hyperkalemia, hyperphosphatemia, hypocalcemia, and acute kidney injury.

98

For fat malabsorption what type of drug is used in what amount?

Pancreatic enzymes are used with each meal or snack that contains fat.
Use 4000 units of lipase perm 5 to 7 grams of fat or 30,000 to 40000 lipase units per meal and
10000 lipase units per snack or
500 lipase units per kilogram with meals and creasing as tolerated
Do not exceed 2500 lipase units per kilogram of body weight per meal

99

What amount of Ginger extract is used for nausea?

0.5-1.0 grams

100

What bulking agent drugs are used for constipation

Bran, flaxseed or wheat germ
Citrucel (methyl cellulose)
Konsyl

101

What type of stool softeners are used for constipation?

Colace
Mineral oil

102

What type of laxatives are used for constipation?

Osmotic laxatives
Miralax, lactulose and milk of magnesia

Stimulant laxatives
Carter's pills (bisacodyl) and Senokot (Senna)

103

Omega 3 fatty acids and fish oil May provide benefits in which Cancer drugs?

May reduce toxicity of
Irinotecan
Pacetaxel

May enhance clinical benefit of
Doxorubicin
Cisplatin
Vincristine

104

Coenzyme Q10 May reduce the toxicity of which chemotherapy drug?

Doxorubicin ( Adriamycin)

It may reduce the renal and cardiotoxicity of this drug

105

Flaxseed May influence which Cancer drug?

It may enhance the efficacy of Tamoxifen

106

Theanine, and amino acid found in tea, May enhance the benefits and reduce the toxicity of which chemotherapy drugs?

What is the dose of benefit?

Doxorubicin

Idarubicin

Dosage is 200 to 400 mg QD /BID; maximum dose of 1200 mg

107

Silymarin, an extract of milk thistle, May reduce the side effects of which cancer drug?

Cisplatin

108

To help avoid mucositis,which drugs can one benefit from using ice chips or an ice pop during the administration of?

5 f U and adriamycin

109

What are the name of some Pro motility drugs used in patients using tube feedings when they're gastric feeding tubes have residual volumes?

Metaclopramide or Erythromycin

110

With which treatment is Mesna typically given to help reduce hemorrhagic cyst?

Ifosfamide (Ifex)
Cyclophosphamide (Cytoxan)

111

Cell cycle specific chemotherapy drugs include:

Alkylating agents
Anti-metabolites
Anti-tumor antibiotics
Anthracyclines
Epiodophyllotoxins
Taxanes
Vinca Alkaloids

112

Drugs ending in -cin will likely have what side effects?

Nausea, vomiting, diarrhea anorexia comma mucositis, red- orange urine, hand-foot syndrome

113

Drugs ending in -nib, -mus, and -mib have what side effects?

Rash, hand-foot syndrome, nausea, vomiting, diarrhea, decreased appetite, hypertension, cardiotoxicity

114

Drugs ending in -taxel will likely have what side effects?

Diarrhea and mucositis

115

Drugs starting with a V and ending in -ine often have what side effects?

Constipation