Chemotherapeutic Drugs (Bacterial, Viral, Fungal) Flashcards Preview

Pharmacology > Chemotherapeutic Drugs (Bacterial, Viral, Fungal) > Flashcards

Flashcards in Chemotherapeutic Drugs (Bacterial, Viral, Fungal) Deck (37):
1

What antibiotics are bactericidal?

BACTERICIDAL ANTIBIOTICS
Very Finely Proficient At Murder!
Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Metronidazole

2

What antibiotics are bacteriostatic?

BACTERIOSTATIC ANTIBIOTICS
We're ECSTaTiC about bacteriostatics
Erythromycin
Clindamycin
Sulfamethprim
Trimethoprim
Tetracycline
Chloramphenicol

3

Mnemonics-Routes of Administration of Penicillins

Pen V is Oral, ipapasok sa Vunganga
Pen G is IV: You inGect Pen G

4

Mnemonics-Nafcillin

Use naf (nafcillin) for staph.

5

Mnemonics-Ampicillin/Amoxicillin

AMPicillin = AMPed up penicillin
amOxicillin = greater Oral bioavailability

6

Describe the antimicrobial coverage of extended spectrum penicillins.

Amoxicillin HELPS kill Enterocci
Haemophilus influenzae
Escherichia coli
Listeria monocytogenes
Proteus mirabilis
Salmonella spp.
Enterococci

7

Mnemonics-Antipseudomonal Penicillins

TCP: Takes Care of Pseudomonas
Ticarcillin
Carbenicillin
Piperacillin

8

Which microbes are covered by the spectrum of activity of first generation cephalosporins?

FIRST GENERATION CEPHALOSORINS
PEcKs FIRST
Proteus mirabilis
Escherichia coli
Klebsiella pneumoniae

9

How do you remember first generation cephalosporins?

FIRST GENERATION CEPHALOSPORINS
FADer, help me FAZ my PHarmacology boards!
CeFADroxil
CeFAZolin
CePHalothin
CePHapirin
CePHradine
CePHalexin

10

Which microbes are covered by spectrum of activity of second generation cephalosporins?

SECOND GENERATION CEPHALOSORINS
HEN PEcKS
Haemophilus influenzae
Enterobacter aerogenes
Neisseria spp.
Proteus mirabilis
Escherichia coli
Klebsiella pneumoniae
Serratia marcescens

11

How do you remember second generation cephalosporins?

SECOND GENERATION CEPHALOSPORINS
In a FAMily gathering, you see your FOXy cousin wearing a FUR coat and drinking TEA.
CeFAMandole, CeFOXitin
CeFURoxime, CefoTEtan
SECOND GENERATION CEPHALOSPORINS
FAC! LORA the PROfessional AZhOLE is still on the FONe.
CeFAClor, LORAcarbef, CefPROzil, CefmetAZOLE, CeFONicid

12

How do you remember third generation cephalosporins?

THIRD GENERATION CEPHALOSPORINS
FEnge PO ng PERA to FIX my TTTTTV!
CeFEtamet
CefPOdoxin
CefoPERAzone
CeFIXime
CefTriaxone
CefTazidime
CefoTaxime
CefTizoxime
CefTibuten

13

Which cephalosporins are anti-pseudomonal?

ANTI_PSEUDOMONAL CEPHALOSPORINS
CefTAZidime
CeFEPime
CeFOPerazone

14

Mnemonics-Imipenem Cilastatin

With Imipenem, the kill is LASTIN with ciLASTatIN.

15

Which antibiotics are considered drugs of last resort?

I AM your Last Shot at Victory
Imipenem
Amikacin
Meropenem
Linezolid
Streptogramins
Vancomycin

16

Mnemonic - Protein Synthesis Inhibitors

BUY AT 30, CELLS AT 50
A=Aminoglycosides
T=Tetracyclines
C=Chloramphenicol
E=Erythromycin (Macrolides)
L=Lincosamides (Clindamycin)
L=Linezolid
S=Streptogramins

17

Mnemonics-Tetracycline

T=TeTracyclines = Block aTTachment of T-RNA to acceptor site

18

Mnemonics-Clindamycin VS Metronidazole

CLINDAMYCIN for anaerobic infections ABOVE the diaphragm.
METRONIDAZOLE for anaerobic infections BELOW the diaphragm.

19

Mnemonics-Aminoglycosides

AminOglycosides require O2 for transport. They won't work under anaerobic conditions.

20

Mnemonics-Aminoglycosides

Mean GNATS canNOT kill anaerobes.
Gentamicin
Neomycin
Amikacin
Tobramycin
Streptomycin

Nephrotoxicity
Ototoxicity
Teratogen

21

Mnemonics-Fluoroquinolones

FloroquinoLONES hurt attachment to your BONES (cartilage damage)

22

Mnemonics-Isoniazid

INH Injures Neurons and Hepatocytes

23

Mnemonics-Rifampicin

R=Rifampicin
RNA Polymerase inhibitor
Red-orange body fluids
Rapid development of resistance
Revs up cytochrome P450 (inducer)

24

Which anti-TB drugs are hepatotoxic?

ISO a Red PYRe!
( I saw a red fire!)
Isoniazid < Rifampin < Pyrazinamide

25

Mnemonics-Foscarnet

FOScarnet = pyroFOSphate analog

26

Mnemonics-NNRTIs

Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs)
Never Ever Deliver Nucleosides
Nevirapine
Efavirenz
Delavirdine

27

Mnemonics-Protease Inhibitors

PROTEASE INHIBITORS
All protease inhibitors end with-navir.
NAVIR (never) TEASE a proTEASE.

28

Mnemonics-Amantadine

AMANTADINE
A man to dine takes off his coat.
Amantadine prevents uncoating.

Amantadine
blocks influenza A and rubellA
causes problems with the cerebellA

29

Mnemonics-Vinca Alkaloids

vinBLASTine BLASTS the Bone marrow
vinblastine causes myelosuppression

30

Mnemonics-Maalox

MAGnesium hydroxide causes diarrhea
MAGtatae ka!
ALUMinum hydroxide causes constipation
Ayaw LUMabas!

31

What are the signs and symptoms of organophosphate poisoning?

DUMBBELSS
Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation (skeletal muscle and CNS)
Lacrimation
Sweating
Salivation

32

Mnemonics-Antimuscarinic Poisoning

HOT as a hare
DRY as a bone
RED as a beet
BLIND as a bat
MAD as a hatter

33

Mnemonics-Opioid Overdose

P-C-R
Pupillary constriction
Comatose state
Respiratory depression

34

Mnemonics-Aspirin Poisoning

C-H-A-F-S
Coma
Hyperventilation
Acidosis (HAGMA)
Fever
Seizure

35

Mnemonics-Sedative-Hypnotic Poisoning

Hot Hot Hot DeCisioN!
Hypothermia
Hypotension
Hypoactive BS
Disinhibition
Coma
Nystagmus

36

Mnemonics-TCA Overdose

3 Cs of TCA Overdose
Coma
Convulsions
Cardiotoxicity

37

KEY LEARNING POINTS-Increased Stool Osmolar Gap

Methanol
Ethanol
Diuretics
Isopropyl alcohol
Ethylene glycol