CHEMOTHERAPEUTIC DRUGS - SYNTHETIC ANTIBACTERIAL DRUGS Flashcards Preview

Pharmacology > CHEMOTHERAPEUTIC DRUGS - SYNTHETIC ANTIBACTERIAL DRUGS > Flashcards

Flashcards in CHEMOTHERAPEUTIC DRUGS - SYNTHETIC ANTIBACTERIAL DRUGS Deck (37):
1

Sulfonamides are effective against

- Bacteria and Chlamidia
- Actinomyces
- Protozoa

2

Mechanism of sulfonamides’ antibacterial effect is

Inhibition of dihydropteroate synthase

3

Combination of sulfonamides with trimethoprim

Increases the antimicrobial activity

4

Sulfonamide potency is decreased in case of co-administration with

Local anesthetics – derivatives of paraaminobenzoic acid

5

The following measures are necessary for prevention of sulfonamide precipitation and crystalluria

Taking of drinks with alkaline pH

6

Resorptive sulfonamides have the following unwanted effects on blood system

- Hemolytic anemia
- Thrombocytopenia
- Granulocytopenia

7

Mechanism of Trimethoprim’ action is

Inhibition of dihydropteroate reductase

8

Sulfonamides have the following unwanted effects

- Hematopoietic disturbances
- Crystalluria
- Nausea, vomiting and diarrhea

9

The drug, which is effective against mycobacteria only

Isoniazid

10

The antimycobacterial drug belonging to first-line agents

Isoniazid

11

The antimycobacterial drug, belonging to second-line agents

PAS

12

The antimycobacterial drug, belonging to antibiotics

Rifampin

13

Mechanism of Izoniazid action is

Inhibition of mycolic acids synthesis

14

Mechanism of Rifampin action is

Inhibition of DNA dependent RNA polymerase

15

Mechanism of Cycloserine action is

Inhibition of cell wall synthesis

16

Mechanism of Streptomycin action is

Inhibition of protein synthesis

17

Rifampin has the following unwanted effect

Flu-like syndrome, tubular necrosis

18

Isoniazid has following unwanted effect

Hepatotoxicity, peripheral neuropathy

19

Ethambutol has the following unwanted effect

Retrobulbar neuritis with red-green color blindness

20

Streptomycin has the following unwanted effect

Ototoxicity, nephrotoxicity

21

Mechanism of aminosalicylic acid action is

Inhibition of folate synthesis

22

The following agents are the first-line antimycobacterial drugs

- Rifampin
- Isoniazid
- Streptomycin

23

The following antimycobacterial drugs have a bactericidal effect

- Streptomycin
- Rifampin
- Isoniazid

24

Combined chemotherapy of tuberculosis is used to

Decrease mycobacterium drug-resistance

25

Antibacterial drug – a nitrofurane derivative

Nitrofurantoin

26

Antibacterial drug – a nitroimidazole derivative

Metronidazole

27

Antibacterial drug – a quinolone derivative

Nalidixic acid

28

Antibacterial drug – a fluoroquinolone derivative

Ciprofloxacin

29

The indications for nitrofuranes

Infections of urinary and gastro-intestinal tracts

30

The unwanted effects of nitrofuranes

- Nausea, vomiting
- Allergic reactions
- Hemolytic anemia

31

The indications for Metronidazole

Intra-abdominal infections, vaginitis, enterocolitis

32

The unwanted effects of Metronidazole

Nausea, vomiting, diarrhea, stomatitis

33

The mechanism of fluoroquinolones’ action is

Inhibition of DNA gyrase

34

Fluoroquinolones are active against

Variety of Gram-negative and positive microorganisms, including Mycoplasmas and Chlamidiae

35

The unwanted effects of fluoroquinolones

Headache, dizziness, insomnia

36

The indications for fluoroquinolones

Infections of the urinary and respiratory tract, bacterial diarrhea

37

The drug of choice for syphilis treatment is

Penicillin

Decks in Pharmacology Class (41):