Flashcards in Chemotherapy Deck (18)
Which chemotherapy agents are associated with SIADH?
Name 2 uses of ATRA.
What is the mechanism of action of asparaginase?
Asparagine depletion; tumor cells lack asparagine synthetase
What is the mechanism leading to hearing loss with cisplatin?
Production of reactive oxygen species, leading to cell death and damage to several areas of the cochlea
Mechanisms of action of rituximab
Monoclonal antibody against CD20; leads to depletion of CD20 cells in blood in lymph nodes, i.e. benign and malignant mature B-lymphocytes
Nelarabine: non-hematological toxicity
Neurological side effects, including: altered mental state, CNS toxicity, peripheral neuropathies, including demyelination (ascending neuropathy, GBS-like)
Risk seems increased if prior radiation therapy or intrathecal chemotherapy
- What is the target?
- List 2 diseases where it has been used
Hodgkin lymphoma, ALCL
Describe the interaction between asparaginase and cytarabine/methotrexate
- Decrease the effect of cytarabine or MTX if given PRE
- Enhance the effect of cytarabine or MTX if given POST
Name 5 drugs interacting with HD methotrexate
- PCP prophylaxis (Septra)
List 5 chemotherapy agents considered as vesicants
- Vinca alkaloids: VCR, vinblastine, vinorelbine
- Anthracyclines, e.g. doxorubicine
- Paxels: docetaxel, paclitaxel
- Nitrogen mustard
- Other: dactinomycin, mitomycin
Which antidotes exist in case of a vesicant?
- Hyaluronidase (vinca alkaloids)
- DMSO (doxorubicin)
- Sodium thiosulfate (nitrogen mustard)
When treating infiltration of a vesicant, it is usually recommended to use cold compresses. However, it is contraindicated with 2 types of substances. Which ones?
- Vinca alkaloids
- Name 2 indications
- Name class
Indications: bladder cancer, malignant, meningeal neoplasms
Class: alkylating agent
What is bortezomib?
- Proteasome inhibitor
- Refractory/relapsed B or T cell ALL
What is blinatumomab?
- Bispecific T-cell engager antibody, targeting CD19
- Refractory/relapsed precursor B-cell ALL
Name serious side effects (2) of blinatumomab
Cytokine release syndrome
Neurologic events, e.g. seizures, confusion, delirium, etc.
Name common symptoms of cytokine release syndrome
- Organ dysfunction: encephalopathy, hepatic dysfunction, ARDS, cardiac dysfunction, acute kidney injury