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Flashcards in Chemotherapy Deck (18)
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1

Which chemotherapy agents are associated with SIADH?

Vincristine
Cyclophosphamide

2

Name 2 uses of ATRA.

- Neuroblastoma
- APML

3

What is the mechanism of action of asparaginase?

Asparagine depletion; tumor cells lack asparagine synthetase

4

What is the mechanism leading to hearing loss with cisplatin?

Production of reactive oxygen species, leading to cell death and damage to several areas of the cochlea

5

Mechanisms of action of rituximab

Monoclonal antibody against CD20; leads to depletion of CD20 cells in blood in lymph nodes, i.e. benign and malignant mature B-lymphocytes

6

Nelarabine: non-hematological toxicity

Neurological side effects, including: altered mental state, CNS toxicity, peripheral neuropathies, including demyelination (ascending neuropathy, GBS-like)

Risk seems increased if prior radiation therapy or intrathecal chemotherapy

7

Brentuximab vedotin:
- What is the target?
- List 2 diseases where it has been used

CD-30
Hodgkin lymphoma, ALCL

8

Describe the interaction between asparaginase and cytarabine/methotrexate

- Decrease the effect of cytarabine or MTX if given PRE
- Enhance the effect of cytarabine or MTX if given POST

9

Name 5 drugs interacting with HD methotrexate

- PPI
- Penicillin
- Penems
- PCP prophylaxis (Septra)
- Acyclovir
- Fluoroquinolones
- NSAIDs

10

List 5 chemotherapy agents considered as vesicants

- Vinca alkaloids: VCR, vinblastine, vinorelbine
- Anthracyclines, e.g. doxorubicine
- Paxels: docetaxel, paclitaxel
- Nitrogen mustard
- Epipodophyllotoxins
- Other: dactinomycin, mitomycin

11

Which antidotes exist in case of a vesicant?

- Hyaluronidase (vinca alkaloids)
- DMSO (doxorubicin)
- Sodium thiosulfate (nitrogen mustard)

12

When treating infiltration of a vesicant, it is usually recommended to use cold compresses. However, it is contraindicated with 2 types of substances. Which ones?

- Vinca alkaloids
- Epipodophyllotoxins

13

Thiotepa:
- Name 2 indications
- Name class

Indications: bladder cancer, malignant, meningeal neoplasms
Class: alkylating agent

14

What is bortezomib?
Indications?

- Proteasome inhibitor
- Refractory/relapsed B or T cell ALL

15

What is blinatumomab?

- Bispecific T-cell engager antibody, targeting CD19
- Refractory/relapsed precursor B-cell ALL

16

Name serious side effects (2) of blinatumomab

Cytokine release syndrome
Neurologic events, e.g. seizures, confusion, delirium, etc.

17

Name common symptoms of cytokine release syndrome

- Fever
- Organ dysfunction: encephalopathy, hepatic dysfunction, ARDS, cardiac dysfunction, acute kidney injury
- Hyperferritinemia

18

What is the management of cytokine release syndrome?

Prevention: dexamethasone given at time of infusion
Management:
- Supportive care
- Consider IL6 inhibitor (tocilizumab) is severe
- Steroids