Chemotherapy Flashcards Preview

4. STEPH PHARM EXAM 4 > Chemotherapy > Flashcards

Flashcards in Chemotherapy Deck (30):
1

what is the most common dose-limiting toxicity in chemotherapy?

myelosuppression

2

what is the order of blood cell decline seen in chemo myelosuppression?

anemia
neutropenia
thrombocytopenia

3

what can you use to treat anticipatory emesis?

benzos - diazepam

4

what can you use to treat refractory emesis?

glucocorticoids

5

what can you use to treat delayed emesis?

aprepitant
fosaprepitant

6

what can you use to treat breakthrough emesis?

prochlorperazine
phenothiazine

7

what can you use to treat acute emesis?

ondansetron

8

what are the most commonly presenting ADEs of chemo?

mucositis
nausea
vomiting

9

how do you treat candida infections in the mouth?

clomitrazole troches
nystatin oral suspension
oral fluconazole
IV amphotericin

10

what drug is used for patients prior to hematopoetic stem cell transplantation?

what are it's ADEs?

palifermin-keratinocyte growth factor (KGF)

increase in serum amylase and lipase

11

how do you treat GI tract mucositis?

lomotil
loperamide

12

how do you treat acral erythema?

pyridoxine
isoniazid (verbalized this)

13

how do you treat hand-foot skin reaction?

topical urea cream
topical steroids

14

how do you prevent extravasation?

large vein
central venous catheters
ice packs to affected areas

anthracyclines
actinomycin
vinca alkaloids

15

what can you give to neutralize nitrogen mustard extravasations?

sodium thiosulfate

16

what is the goal hemoglobin for maximum benefit?

10-12

17

when are CSF factors used?

primary or secondary prophylaxis of neutropenia

18

what are ADEs of CSF factors?

bone pain
increased LDH, alk phos, uric acid levels, LFTs
fever, myalgia, headache

19

when do you do a platelet transfusion?

<10,000 cells

20

what are the ADEs of oprelvekin (a thrombocytopenia drug)?

fluid retention
tachy
A fib
A flutter
fluid retention
heart failure

21

neuropathy is most often associated with what drugs?

vinca alkaloids
taxane drugs

22

what are the "bright red drugs" and what are their ADEs?

anthracyclines
cardiotoxicity

23

if the LVEF is >___% you can give anthracyclines

50%

24

what drug causes pulmonary fibrosis in the elderly?

bleomycin

25

how do you treat mucositis?

- dental visit prior to treatment
- rinse with baking soda/salt water

26

how do you treat severe cases of chemo-induced diarrhea?

octreotide

27

what drugs can you give to treat alopecia?

taxane
docetaxel

28

what are the severe ADEs of recombinant human EPO?

decreased survival
thrombosis
red cell aplasia

29

when do you stop giving pegfilgrastim?

14 days before next dose of chemo

30

how do you treat ADEs associated with cisplatin?

amifostine