Flashcards in Chemotherapy, Biotherapy & Targeted Therapy Deck (16):
What are local treatments?
Surgery and XRT
What are systemic treatments?
What grade is best?
G1: well differentiated
What grade is worse?
G4: undifferentiated or poorly differentiated
What does tumor staging (TNM) do?
-look at extent of disease
-evaluates treatment response
What are goals of chemo?
What are principles of chemotherapy?
-Adjuvant (with surgery)
-Neoadjuvant (before surgery)
Chemo vs. Targeted Therapy
-kills all fast multiplying cells
-interrupts normal cellular division
-dosed by BSA
-goes directly towards tumor/site
-interferes with specific molecules/signaling pathways
-pt must exhibit positive testing for target
-dosed in my, units, m2
What are cell cycle specific drugs?
Act on certain phase of cell cycle
-best in divided doses or continuous infusion w/ short cycle
-acts on rapidly growing & dividing cells
Examples: Vincristine, Antimetabolites (MTX)
What are cell-cycle non-specific drugs?
Act during all phases of cell cycle
-best on slow dividing/fewer cells
Examples: Anti-tumor antibiotics, Alkylating Agents, Nitrourias
Benefits of combo chemo
Different mechanisms of action
Decrease in drug resistance
What is Biotherapy?
-Uses body's immune system to create a response
-Stimulate or suppress immune system
-cause antitumor activities
Conjugated: not attached; pure
Unconjugated: attached to chemo or radioactive isotopes/toxins
How does tumor burden influence therapy response?
-smaller tumor=better response
-fast growing cells respond better to chemo
How does hormone receptor therapy influence response?
Tumors that grow fast with certain hormones may benefit from hormonal therapy
Types of chemo exposure?