Chemotherapy, Biotherapy & Targeted Therapy Flashcards Preview

Pathobiology of Neoplasia > Chemotherapy, Biotherapy & Targeted Therapy > Flashcards

Flashcards in Chemotherapy, Biotherapy & Targeted Therapy Deck (16):
1

What are local treatments?

Surgery and XRT

2

What are systemic treatments?

-Chemo
-Biotherapy
-Targeted Therapy
-Hormonal Therapy

3

What grade is best?

G1: well differentiated
-best prognosis

4

What grade is worse?

G4: undifferentiated or poorly differentiated

5

What does tumor staging (TNM) do?

-look at extent of disease
-treatment decisions
-prognostic info
-evaluates treatment response

6

What are goals of chemo?

-cure
-control
-palliation

7

What are principles of chemotherapy?

-Adjuvant (with surgery)
-Neoadjuvant (before surgery)
-Chemoprevention
-Myeloablation

8

Chemo vs. Targeted Therapy

Chemo
-kills all fast multiplying cells
-interrupts normal cellular division
-dosed by BSA

Targeted
-goes directly towards tumor/site
-interferes with specific molecules/signaling pathways
-pt must exhibit positive testing for target
-dosed in my, units, m2

9

What are cell cycle specific drugs?

Act on certain phase of cell cycle
-best in divided doses or continuous infusion w/ short cycle
-acts on rapidly growing & dividing cells

Examples: Vincristine, Antimetabolites (MTX)

10

What are cell-cycle non-specific drugs?

Act during all phases of cell cycle
-best on slow dividing/fewer cells

Examples: Anti-tumor antibiotics, Alkylating Agents, Nitrourias

11

Benefits of combo chemo

Synergistic effect
Decreased toxicity
Different mechanisms of action
Decrease in drug resistance

12

What is Biotherapy?

-Uses body's immune system to create a response
-Stimulate or suppress immune system
-cause antitumor activities

Conjugated: not attached; pure
Unconjugated: attached to chemo or radioactive isotopes/toxins

13

How does tumor burden influence therapy response?

-smaller tumor=better response
-fast growing cells respond better to chemo

14

How does hormone receptor therapy influence response?

Tumors that grow fast with certain hormones may benefit from hormonal therapy

15

Types of chemo exposure?

Absorption
Injection
Inhalation
Ingestion

16

Characteristics of cancer cells

-Abnormal proliferation
-lack of controlled cell growth and division
-Ability to spread and invade