cholesterol Flashcards Preview

Pharm > cholesterol > Flashcards

Flashcards in cholesterol Deck (18)
Loading flashcards...
1
Q

HMG-CoA reductase inhibitors adverse effects

A

myopathy, hepatotoxicity

2
Q

Bile acid sequestrants adverse effects

A

GI distress, decrease in vitamin absorption

3
Q

Niacin adverse effects

A

flushing, hyperglycemia, hyperuricemia, hepatotoxicity,, upper GI distress

4
Q

Fibrates adverse effects

A

dyspepsia, gallstones, myopathy

5
Q

HMG-CoA reductase inhibitors contraindications

A

liver disease, pregnancy

6
Q

Bile acid sequestrants contraindications

A

dysbetalipoproteinemia, TG>400

7
Q

Niacin contraindications

A

liver disease, gout

8
Q

Fibrates contraindications

A

renal and liver disease

9
Q

Colesevelam, cchikestyramine and colestipol are which kids of med?

A

Bile acid sequestrants

10
Q

Gemfibrozil (lopid) and Fenofibrare (Tricor) are which kinds of med?

A

Fibrate

11
Q

Fibrates and warfarin interaction

A

increases risk for bleeding

12
Q

can you combine bile acid sequestrants with a statin?

A

yes

13
Q

can you combine fibrates with a statin?

A

no just fibricor

14
Q

VLDL

A

deliver TG from liver to tissue and muscle

15
Q

LDL

A

deliver cholesterol to nonhepatic tissues

16
Q

apoliporoteins

A

increase structural stability of lipoproteins, activate enzymes that metabolize lipoproteins and allow cells to bind with and ingest lipoproteins

17
Q

who would benefit from a statin? (4)

A
  • patients with ASCVD
  • patients with LDL >190
  • 40-75 year old diabetics with LDL 70-189
  • 40-75 year old no ASCVD or non diabetics with LDL 70-189 and a ASVD risk of 7.5%
18
Q

metabolic syndrome

A

metabolic abnormalities associated with an increased risk for ASCVD and type 2 diabetes