Cholinergic Agonists and Antagonists Flashcards
(30 cards)
1
Q
Acetylcholine
A
Agonist - DA
- Decreases HR and BP
- therapeutically of no importance
2
Q
Bethanechol
A
Agonist - DA
- Increases intestinal motility and tone
- Stimulates detrusor muscles of the bladder
- used often for non obstructive urinary retention (postpartum, post-op)
3
Q
Carbachol
A
Agonist - DA
- pupillary contraction
- decreased IOP
- treatment of glaucoma
- high potency, long duration of action
4
Q
Pilocarpine
A
Agonist -DA
- lowers IOP immediately (good for emergency situations)
- increases drainage of aqueous humor
5
Q
Cevimeline
A
Agonist -IAR
- used for treatment of dry mouth and lack of tears
- treatment of Sjogrens syndrome
6
Q
Edrophonium
A
Agonist - IAR
- increases muscle strength
- used in diagnosis of myasthenia graves (tension test)
7
Q
Physostigmine
A
Agonist - IAR
- increases intestinal and bladder motility
- produces miosis, spasm and decreases IOP
- antidote for atropine, etc.
8
Q
Neostigmine
A
Agonist - IAR
- stimulates bladder and GI tract
- antidote for tubocurarine
- treatment of myasthenia gravis
9
Q
Pyridostigmine
A
Agonist - IAR
- cholinesterase inhibitor
- chronic management of myasthenia gravis
10
Q
Ambenomium
A
Agonist - IAR
- cholinesterase inhibitor
- chronic management of myasthenia gravis
11
Q
Tacrine
A
Agonist - IAR
- delays progression of Alzheimer’s disease
- been replaced b/c of its hepatotoxicity
12
Q
Donepezil
A
Agonist - IAR
-delays progression of Alzheimer’s disease
13
Q
Rivastigmine
A
Agonist - IAR
-delays progression of Alzheimer’s disease
14
Q
Galantamine
A
Agonist - IAR
-delays progression of Alzheimer’s disease
15
Q
Echothiophate
A
Agonist - IAI
- open-angle glaucoma treatment
- not a first line treatment
16
Q
Pralidoxime
A
Agonist - Reactivation of AChE inhibitor
-Reactivation of AChE
17
Q
Atropine
A
Antagonist
- antimuscarinic
- antispasmodic (relaxes GI and bladder)
- antidote for cholinergic agonists
- antisecretory (for surgery)
18
Q
Scopolamine
A
Antagonist
- antimuscarinic
- prevention of motion sickness
- blocks short term memory
- adjunct w/anesthetic procedures
19
Q
Ipratropium
A
Antagonist
- antimuscarinic
- treatment of asthma for pts who cannot take adrenergic agonists
- mangement of bronchospasm (COPD, chronic bronchitis, emphysema)
20
Q
Tiotropium
A
Antagonist
- antimuscarinic
- treatment of asthma for pts who cannot take adrenergic agonists
- mangement of bronchospasm (COPD, chronic bronchitis, emphysema)
21
Q
Tropicamide
A
Antagonist
- antimuscarinic
- ophthalmic use of madrases and cycloplegia
22
Q
Cyclopentolate
A
Antagonist
- antimuscarinic
- ophthalmic use of madrases and cycloplegia
23
Q
Benztropine
A
Antagonist
- antimuscarinic
- useful as adjuncts with other antiparkinsons agents
24
Q
Trihexyphenidyl
A
Antagonist
- antimuscarinic
- useful as adjuncts with other antiparkinsons agents
25
Darifenacin, fesoterodine, oxybutynin, solifenacin, tolerodine and triopsium chloride
Antagonist
- antimuscarinic
- treatment of overactive urinary disease
26
Nicotine
Antagonist
- ganglionic blocker
- no therapeutic benefit
27
Mecamlylamine
Antagonist
- ganglionic blocker
- lowers BP in emergency situations (IV)
28
Curare
Antagonist - NMB
- non depolarizing
- used as an adjunct with anesthesia to relax skeletal muscles
- intubation, ortho surgery
29
Tubocurnine
Antagonist - NMB
- non depolarizing (competitive)
- used as an adjunct with anesthesia to relax skeletal muscles
- intubation, ortho surgery
30
Succinylcholine
Antagonist - NMB
- depolarizing
- useful for rapid endotracheal intubation
- used w/electroconvulsive shock treatment
