cholinergic receptors Flashcards
M1location
o Autonomic ganglia
o Gastric glands
o CNS (Cortex & hippocampus) o Salivary glands
M1 func
o Depolarisation
o Histamine release, acid secretion
o Learning, Memory, Motor function
o Salivary secretion
M2 LOCATION
o SA Node
o AV Node
o Atrium
o Ventricle
o Cholinergic Nerve Ending o CNS
o Visceral Smooth Muscle
M2 FUNC
o Hyperpolarization, ↓ impulse generation
o ↓ velocity of conduction
o Shortening of action potential duration, ↓
contractility
o ↓ contractility
o ↓ Acetylcholine release o Tremor, Analgesia
o Contraction
M3 LOCATION
o Visceral Smooth Muscle
o Iris
o Ciliary Muscle
o Exocrine Glands
o Vascular Endothelium
M3 FUNC
o Contraction
o Constriction of Pupil
o Contraction
o Secretion
o Vasodilatation due to Nitric Oxide release
NM LOCATION
Neuromuscular Junction
NM FUNC
Depolarization of muscle end plate – Contraction of skeletal muscle
NN LOCATION
o Autonomic Ganglia
o Adrenal Medulla
o CNS
NN FUNCTION
o Depolarization – postganglionic impulse
o Release of Catecholamines
o Site specific excitation/inhibition
eye
M3
HEART
M2
VESSLES
M3
RESPI SYSTEM
M3
GI
INCREASE HCL -M1
INCREASE MOTILITY -M3
INCREASE SALIVARY N GASTRIC SECRETIONS-M3
