Cholinergic Receptors (Direct & Indirect Agonists) Flashcards Preview

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Flashcards in Cholinergic Receptors (Direct & Indirect Agonists) Deck (8)
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1
Q

What are the main actions of M1, M2, and M3?

A

M1: Enteric and CNS
M2: Heart depression
M3: Vasodilation, Gland secretion, GI smooth muscle contraction, Miosis

2
Q

What are the direct agonists of aceytlcholine?

A

Metacholine and Bethanechol. Both are more resistant to hydrolysis than ACh

3
Q

What are the 3 groups of indirect acting cholinomimetics?

A
  1. Simple alcohols (short DOA)
  2. Carbamic acid esters (Intermediate DOA)
  3. Organic derivatives of phosphoric acid (Long lasting DOA)
4
Q

Discuss Edrophonium

A

(Simple Alcohol)Reversibly binds to cholinesterases, preventing ACh from binding them. Used to test myasthenia gravis

5
Q

Name the carbamates

A

Neostigmine, pyridostigmine

6
Q

Name the organophosphates

A

Parathion, malathion, soman and sarin

7
Q

Discuss the toxicity of cholinomimetics

A

SLUDGE; salivation, lacrimation, urination, defecation, GI motility, Eye miosis

8
Q

What 2 pathological circumstances can AChE inhibitors be useful?

A
  1. Myasthenia gravis: AChE inhibitors enhance action of ACh at NMJs
  2. Alzheimer Disease: AChE inhibitors slow progression of symptoms.