Flashcards in Cholinergics! Deck (9)
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1
Which G-protein coupled muscarinic receptors work through the same pathway as alpha 1?
M1, M3 and M5
2
Which G-protein coupled muscarinic receptors inhibit adenylyl cyclase and reduce cAMP?
M2, M4
3
Location of action for M1, M2, M3, M4, M5, Nm and Nn receptor subtypes.
M1-CNS, stomach
M2- Cardiac muscle, CNS and airway smooth muscle
M3- airway smooth muscle, glandular tissue
M4-CNS
M5- CNS
Nm- skeletal muscle at NMJ
Nn- autonomic ganglia, adrenal medulla CNS
4
Anti-muscarinic drugs competitively antagonize ACh where?
at muscarinic receptors only.
5
What is the more detailed MOA of antimuscarinic drugs?
Cation potion of the drug fits into Ach's place on the cholinergic receptor and reversibly inhibits Ach binding.
6
What kind of responses do antimuscarinic drus allow to predominate?
Sympathetic.
7
How is the competitive inhibition of antimuscarinic drugs reversed?
If the ACh concentration is increased.
8
Structurally why do we care about atropine and scopalamine?
They are tertiary amines- alkaloids of the belladonna plants which CAN cross the BBB.
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