Flashcards in Cholinergics! Deck (9)
Which G-protein coupled muscarinic receptors work through the same pathway as alpha 1?
M1, M3 and M5
Which G-protein coupled muscarinic receptors inhibit adenylyl cyclase and reduce cAMP?
Location of action for M1, M2, M3, M4, M5, Nm and Nn receptor subtypes.
M2- Cardiac muscle, CNS and airway smooth muscle
M3- airway smooth muscle, glandular tissue
Nm- skeletal muscle at NMJ
Nn- autonomic ganglia, adrenal medulla CNS
Anti-muscarinic drugs competitively antagonize ACh where?
at muscarinic receptors only.
What is the more detailed MOA of antimuscarinic drugs?
Cation potion of the drug fits into Ach's place on the cholinergic receptor and reversibly inhibits Ach binding.
What kind of responses do antimuscarinic drus allow to predominate?
How is the competitive inhibition of antimuscarinic drugs reversed?
If the ACh concentration is increased.
Structurally why do we care about atropine and scopalamine?
They are tertiary amines- alkaloids of the belladonna plants which CAN cross the BBB.