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Flashcards in Cholinergics! Deck (9)
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1

Which G-protein coupled muscarinic receptors work through the same pathway as alpha 1?

M1, M3 and M5

2

Which G-protein coupled muscarinic receptors inhibit adenylyl cyclase and reduce cAMP?

M2, M4

3

Location of action for M1, M2, M3, M4, M5, Nm and Nn receptor subtypes.

M1-CNS, stomach
M2- Cardiac muscle, CNS and airway smooth muscle
M3- airway smooth muscle, glandular tissue
M4-CNS
M5- CNS
Nm- skeletal muscle at NMJ
Nn- autonomic ganglia, adrenal medulla CNS

4

Anti-muscarinic drugs competitively antagonize ACh where?

at muscarinic receptors only.

5

What is the more detailed MOA of antimuscarinic drugs?

Cation potion of the drug fits into Ach's place on the cholinergic receptor and reversibly inhibits Ach binding.

6

What kind of responses do antimuscarinic drus allow to predominate?

Sympathetic.

7

How is the competitive inhibition of antimuscarinic drugs reversed?

If the ACh concentration is increased.

8

Structurally why do we care about atropine and scopalamine?

They are tertiary amines- alkaloids of the belladonna plants which CAN cross the BBB.

9

Structurally why do we care about gycopyrrolate/Robinal?

It is a quaternary ammonium derivative that CANNOT cross the BBB.